HPLC考察硫酸头孢噻利在右旋糖酐注射液中的配伍稳定性  

Compatible Stability of Cefoselis Sulfate for Injection in Dextran 40 Glucose Injection by HPLC

作　　者：朱雅艳[1] 华俊彦[1] 田伟强[1] 张颖异[2] 

机构地区：[1]丽水市中心医院药剂科,浙江丽水323000 [2]温州医学院药学院,浙江温州325035

出　　处：《中国现代应用药学》2011年第12期1132-1135,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省医学会基金项目(2007ZYC57)

摘　　要：目的考察注射用硫酸头孢噻利在右旋糖酐40葡萄糖注射液中的配伍稳定性。方法考察配伍液分别在4,25,37℃下,6 h内外观、pH值的变化,同时采用高效液相色谱法(HPLC)测定配伍液中硫酸头孢噻利的含量变化。结果在4,25,37℃下配伍液6 h内外观、pH值、含量无明显变化。结论硫酸头孢噻利与右旋糖酐40葡萄糖注射液在6 h内配伍稳定。OBJECTIVE To study the compatible stability of cefoselis sulsate for injection in dextran 40 glucose injection. METHODS Investigated the transmutation of the compatible fluid in appearance, pH value in 6 h at 4, 25, 37 ℃, then determined the content of cefoselis sulsate in dextran 40 glucose injection by HPLC. RESULTS There were no obvious changes in appearance, pH value, and also no significant changes in the content of the compatible fluid in 6 h at 4, 25, 37 ℃. CONCLUSION The cefoselis sulsate for injection is stable in 6 hours after mixing with dextran 40 glucose injection.

关 键 词：高效液相色谱法 硫酸头孢噻利 配伍 稳定性 

分 类 号：R927.13[医药卫生—药学] R917.101