HbA_1c与冠状动脉病变程度的相关性研究  

Correlation between HbA_1c level and severity of coronary artery disease

作　　者：王鹏[1] 陈庆伟[1] 李兴升[1] 吴志勤[1] 李桂琼[1] 柯大智[1] 邓玮[1] 王丽[1] 莫显刚[1] 曹广煜[1] 杨彦[1] 张亚梅[1] 肖雷[1] 

机构地区：[1]重庆医科大学附属第二医院老年心血管病科,400010

出　　处：《中国糖尿病杂志》2011年第12期914-917,共4页Chinese Journal of Diabetes

摘　　要：目的探讨HbA_1c水平与冠状动脉病变程度的相关性及临床意义。方法对临床疑诊或诊断为冠心病(CHD)而行冠状动脉造影的541例患者进行HbA_1c测定分组,评价HbA_1c水平与CHD、冠脉狭窄程度(Gensini积分法)、冠脉狭窄支数及接受PCI治疗等的相关性。结果随HbA_1c水平升高,CHD患病率显著上升(P<0.01),Spearman等级相关分析显示,HbA_1c与CHD、病变支数、Gensini积分和接受PCI治疗显著相关(r=0.211,P<0.01;r=0.213,P<0.01;r=0.233,P<0.01;r=0.137,P<0.01)。Logistic多元逐步回归分析结果显示,HbA_1c为CHD的独立危险因素(OR=1.436,95%CI为1.128～1.828,P<0.01)。结论 HbA_1c与冠脉病变程度呈正相关,长期升高可能促进CHD的发生。Objective To study the relationship between glycosylated hemoglobin （HbA1 c） level and severity of coronary artery disease. Methods 541 cases with suspected or confirmed coronary heart disease undergoing coronary angiography were grouped according to the level of HbA1 c. The relationship of HbA1 c level with coronary heart disease, coronary stenosis （Gensini score method）, number of diseased coronary branches and acceptance of PCI treatment was evaluated. Results Along with the increased HbA1 c level, the prevalence of coronary heart disease was significantly higher（P〈0. 01）. Spearman rank correlation test showed that HbA1c level had a positive correlation with coronary heart disease, number of diseased coronary branches, Gensini＇s score or PCI （r=0. 211,P〈0. 01;r=0. 213,P〈0.01 ;r=0. 233,P 〈0.01;r=0. 137 ,P〈0. 01）. Multiple logistic regression analysis showed that HbA1 c was an independent risk factor for CHD（OR=1. 436,95%CI 1.128 -1. 828 , P〈0.01）. Conclusion HbAlc level is positively correlated with the coronary artery disease and has a predictive value of CHD.

关 键 词：糖化血红蛋白 冠心病 冠脉狭窄程度积分 经皮冠状动脉介入 

分 类 号：R541.4[医药卫生—心血管疾病]