弥漫性肺间质疾病中医证候及其临床特征分析  

Study on TCM syndromes and clinical features of diffuse interstitial lung disease

作　　者：李亚[1] 李素云[1] 李建生[1,2] 王明航[1] 王海峰[1] 邓丽[2] 赵栋梁[2] 田燕歌[2] 姜素丽[2] 杨小静[1] 

机构地区：[1]河南中医学院第一附属医院呼吸病研究室,郑州450000 [2]河南中医学院老年医学研究所,郑州450008

出　　处：《中华中医药杂志》2011年第12期2852-2855,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河南省高校新世纪优秀人才支持计划(No.2006HANCET-05)~~

摘　　要：目的:通过对住院病例的回顾性调查,探讨弥漫性肺间质疾病中医证候及其临床症状特征,以指导中医临床辨证。方法:根据对弥漫性肺间质疾病中医临床研究的流行病学调查要求,制订《弥漫性肺间质疾病回顾性研究调查表》,并据其建立弥漫性肺间质疾病证候研究数据库,采用SPSS 13.0 For Windows统计软件进行统计描述、Logistic回归分析和聚类分析进行数据处理。结果:共收集到合格病例475例,中医证候诊断出现频率较高的证候为痰热壅肺证(37.47%)、痰瘀阻肺证(32.00%)、肺肾气虚证(31.58%)、痰湿(浊)阻肺证(17.89%)、气阴两虚证(14.32%)等;根据各主要证候的症状特征构建的Logistic回归方程,对证候的判别准确率达74%以上;结合专业知识对主要症状进行聚类分析,得到痰瘀阻肺证、痰湿(浊)阻肺证、痰热壅肺证、肺肾气虚证、气阴两虚证5个基本类别。结论:弥漫性肺间质疾病主要证候有痰瘀阻肺证、痰湿(浊)阻肺证、痰热壅肺证、肺肾气虚证、气阴两虚证等,可作为进一步开展弥漫性肺间质疾病中医证候研究参考和依据。Objectives： To investigate the basic syndrome types and their main symptom features of diffuse interstitial lung disease（DILD） through the retrospective investigation of hospitalized cases,for guiding TCM differentiation.Methods： Based on the requirements of TCM epidemiological investigation of DILD clinical research,Diffuse Interstitial Lung Disease Retrospective Study Questionnaire was set up,and also the database of TCM essential elements and syndromes.SPSS 13.0 For Windows software was adopted for statistical description with logistic regression,cluster analysis.Results： 475 qualified cases were collected,the main syndrome types of DILD with higher incidence frequencies including syndrome of phlegm-heat blocking lung（37.47%）,syndrome of phlegm-stasis blocking lung（32.00%）,syndrome of lung-kidney qi deficiency（31.58%）,syndrome of phlegm-dampness blocking lung（17.89%）,syndrome of both qi and yin deficiency（14.32%）,and ect..The accuracy of syndrome identification of logistic regression equations based on the symptom features of various syndrome types are higher than 74%;combined with the professional knowledge,in the cluster analysis for main symptoms,5 clusters are acquired,including syndrome of phlegm-stasis blocking lung,syndrome of phlegm-dampness blocking lung,syndrome of phlegm-heat blocking lung,syndrome of lung-kidney qi deficiency and syndrome of both qi and yin deficiency.Conclusions： There are 5 main types of DILD： syndrome of phlegm-stasis blocking lung,syndrome of phlegm-dampness blocking lung,syndrome of phlegm-heat blocking lung,syndrome of lung-kidney qi deficiency and syndrome of both qi and yin deficiency,and this can provide references and foundations for further study of syndrome identification of PF in the future.

关 键 词：弥漫性肺间质疾病 中医证候 回顾性调查 

分 类 号：R259[医药卫生—中西医结合]