高尿酸血症对血清一氧化氮及内皮素-1水平的影响  

Effect of Hyperuricemia to NO and ET-1 Serum Level

作　　者：周传堃[1] 鲁跃华[1] 葛正庆[1] 

机构地区：[1]成都大学附属医院,四川成都610081

出　　处：《现代临床医学》2011年第6期427-428,共2页Journal of Modern Clinical Medicine

摘　　要：目的:观察高尿酸血症对血清一氧化氮(NO)及内皮素-1(ET-1)水平的影响。方法:检测92例观察对象血尿酸水平,分为高血尿酸组(HUA)45例与正常血尿酸组(NUA)47例,分别检测2组每一个体的血清NO及ET-1水平进行比较分析。结果:HUA组NO水平低于NUA组(P<0.01);HUA组ET-1水平高于NUA组(P<0.01)。结论:高尿酸血症可升高血清ET-1水平及降低NO水平,从而导致血管内皮功能障碍,它与动脉粥样硬化及高血压等心血管疾病有密切联系。Objective：To evaluate the effect of hyperuricemia to NO and ET-1 serum level.Methods：NO and ET-1 serum level was measured in 45 patients with hyperuicemia（HUA） and 47 normal uric acid subjects（NUA）.Results：NO level in HUA was siguificautly lower than that in NUA（P〈0.01）,ET-1 level in HUA was siguificautly higher than that in NUA（P〈0.01）.Conclusion：hyperuricemia is a risk factor of endothelial dysfunction,and it is correlated with hypertension and athrosclerosis.

关 键 词：高尿酸血症 一氧化氮 内皮素-1 血管内皮功能 

分 类 号：R589.4[医药卫生—内分泌]