苯那普利对原发性高血压患者血浆内皮素及心钠素的影响  

The effects of benazepril on plasma endothelin and atrial natriuretic factor in hypertensives

作　　者：张苗[1] 袁开芬[1] 马加[1] 姜雪梅[1] 

机构地区：[1]昆明医学院第二附属医院干疗科,昆明650101

出　　处：《临床心血管病杂志》1999年第12期553-554,共2页Journal of Clinical Cardiology

摘　　要：目的：测定原发性高血压（EH）患者血浆内皮素（ET）及心钠素（ANP），并进行治疗前后对比研究。方法：对36例EH用苯那曾利治疗3周，于治疗前1天及治疗后当天，用放免法测定ET及ANP，并与25例健康者作比较。结果：患者ET及ANP均高于正常对照组；ET含量且随病情加重而明显增高，Ⅰ、Ⅱ、Ⅲ期患者间比较差异有显著性（P＜0．01）；EH患者经苯那普利治疗后ET及ANP均明显降低（P＜0．05及P＜0．01）。结论：ET及ANP在EH发病中起着重要作用，转换酶抑制剂是治疗EH较为理想的药物。Objective:To investigate the effect of benazepril on plasma endothelin (ET) and a-trial natriuretic factor (ANP) in patients with essential hypertension (EH). Method: 36 cases withEH were treated with benazepril 10～20 mg/d for 3 weeks. Plasma ET and ANP were determinedby radioimmunoassey before and after treatment. They were also determined at the same times in25 healthy controls for compare. Result: The levels of plasma ET and ANP in EH were significantlyhigher than controls. The amount of ET increased with severity of EH,there were significant dif-ferences between stage Ⅰ、 Ⅱ and Ⅲ of EH (P＜0.01). After benazepril treatment,the levels ofET and ANP in EH were decreased significantly (P＜ 0.05. P ＜0.01 respectively). Conclusion:ET and ANP play important role in the pathogenesis of EH. Transferase inhibitors are ideal drugsin the treatment of EH.

关 键 词：高血压 心钠素 苯那普利 内皮素 

分 类 号：R544.1[医药卫生—心血管疾病]