阻断肾素-血管紧张素-醛固酮系统对自发性高血压大鼠左室肥厚及心肌纤维化的逆转作用  

The regression of LVH and myocardial fibrosis in SHR after blockage of the RAAS at different sites

作　　者：胡英[1] 蔡乃绳[1] 沈学东[1] 杨英珍[1] 陈灏珠[1] 

机构地区：[1]上海医科大学中山医院

出　　处：《临床心血管病杂志》1999年第12期564-567,共4页Journal of Clinical Cardiology

摘　　要：目的：观察阻断肾素-血管紧张素-醛固酮系统不同部位对高血压左室肥厚（LVH）及心肌纤维化的逆转作用。方法：对26周龄自发性高血压大鼠（SHR）分别采用血管紧张素转换酶抑制剂（ACEI）──苯那普利（A组）、AgⅡ－AT1──氯沙坦（B组）、醛固酮受体阻断剂──安体舒通（C组）治疗12周，观察治疗前后大鼠血压、心肌重量、心肌间质胶原的变化。另取26周龄（D组）、38周龄（E组）Wistar大鼠和26周龄（F组）、38周龄（G组）未做任何治疗的SHR作为对照。结果：F组、G组的血压、左室重量／体重（LVW／BW）、胶原及Ⅰ型、Ⅲ型胶原所占的容积百分比含量均高于D组、E组。A组上组经治疗后，血压、LVW／BW、胶原含量及Ⅰ型、Ⅲ型胶原容积分数均较未治疗的G组明显下降（P＜0．05）。C组血压、LVW／BW无明显下降，而胶原含量及Ⅰ型、Ⅲ型胶原容积分数明显降低（P＜0．05）。结论：ACEI、AgⅡ-AT1阻断剂明显降低血压，逆转LVH，消退心肌纤维化；而醛固酮受体阻断剂未能很好降压，对LVH的逆转作用不大，但对心肌纤维化的消退有一定作用。Obective: To observe the effect of blockage of the renin-angiotensin-aldosteronesystem at different sites on the regression of left ventricular hypertrophy(LVH) and myocardial fi-brosis in SHR. Method:Spontaneously hypertensive rats (SHR) were treated by benazapril,losar-tan or spironolactone. Blood pressure, left ventricular weight,myocardial collagen content and thecollagen volume fraction(CVF) both of type Ⅰ and typeⅢ was measured before and after thetreatment. 10 Wistar rats and untreated SHR were selected as control. Result:The blood pressure,LVW/BW and collagen contents as well as CVF (both of type Ⅰ and Ⅲ ) were all higher in SHRthan in Wistar rats. Benazapril and losartan treatment could reduce the blood pressure,LVW/BWand collagen content,also the CVF of both of type Ⅰ and tyPeⅢ (P ＜0.05),but spironolactonecould only reduce the collagen content (P＜0.05) and the CVF (P＜0.05) without reduction ofblood pressure and LVW/BW. Conclusion:All of the three drugshad the same effects on the my-ocardial fibrosis. Whereas administration of ACEI and AgⅡ-AT1 antagonist could reduce the bloodpressure,regress LVH but the spironolactone failed.

关 键 词：高血压 左室肥厚 RAAS 心肌纤维化 大鼠 

分 类 号：R544.106[医药卫生—心血管疾病] R541.902[医药卫生—内科学]