急性心肌梗死患者治疗前后外周血树突状细胞亚群变化  

Study on the Effect of Treatment on Subgroups of Dendritic Cells in Peripheral Blood of Patients with Acute Myocardial Infarction

作　　者：张魏巍[1] 李志樑[1] 靳文[1] 傅强[1] 付晓华[1] 刘映峰[1] 

机构地区：[1]广州南方医科大学附属珠江医院心内科,广州510282

出　　处：《数理医药学杂志》2011年第6期654-658,共5页Journal of Mathematical Medicine

基　　金：2009年度广东省自然科学基金(9151051501000056);广州市科技计划项目(2009B030801206)

摘　　要：目的:探讨急性心肌梗死患者治疗前后外周血树突状细胞亚群数量及比例变化情况。方法:入选病例为我院从2006年1月～2006年12月共20例急性心肌梗死患者;分别留取入院即刻及治疗1周后上述患者外周血标本。借助四色荧光标记技术对外周血髓源性树突状细胞(myeloid DCs,mDCs)和浆细胞样树突状细胞(plasmacytoid dendritic cell,pDC)占DCs细胞比例进行流式细胞术测定。结果:治疗1周后,患者外周血mDCs和pDC占PBMC比例分别为(15.02±7.3)‰、(0.82±0.65)‰,mDC比例较治疗前((4.97±2.7)‰)有显著性差异(P<0.05)。结论:急性心肌梗死患者经治疗1周后,外周血mDC亚群比例和数量明显升高,提示mDC亚群比例和数量的变化与冠心病病情发展密切相关。Objective： To explore the effect of treatment on the significance of the change of subgroups of dendritic cells and inflammatory factors in peripheral blood of patients with coronary artery disease.Methods： 20 patients with acute myocardial infarction（AMI） were recruited in this study.Levels of peripheral myeloid dendritic cell（mDC） and plasmacytoid dendritic cell（pDC） precursors were determined by FACS before and after one week of treatment.Result： We found that mDC and pDC in peripheral blood account for 15.02±7.3‰ and 0.82±0.65‰,respectively,of all PBMC number after treatment.mDC proportion after therapy were more than before significantly（P〈0.05）.Conclusion： mDCs subgroup proportions levels in the peripheral blood of AMI cases increased significantly at 1 week after treatment.These suggest that there may be a highly relationship between mDCs subgroup proportions and the development of acute myocardial infarction.

关 键 词：急性心肌梗死 动脉粥样硬化 髓源性树突状细胞 浆细胞样树突状细胞 治疗 

分 类 号：R542.22[医药卫生—心血管疾病]