丹参酮凝胶剂的释药性研究  

Studies of Drug Releasing Properties on Gels Containing Tanshinone

作　　者：马树人[1] 钟天耕[1] 于筛成[1] 张琳[1] 钱速越 

机构地区：[1]华东理工大学,200237

出　　处：《中成药》1999年第12期617-619,共3页Chinese Traditional Patent Medicine

摘　　要：目的：研究丹参提取物丹参酮亲水凝胶的释药性。方法：以卡波姆（Ｃａｒｂｏｍｅｒ） 、羟丙基甲基纤维素（ＨＰＭＣ） 和聚乙烯吡咯烷酮（ＰＶＰ） 为基质，制备丹参酮亲水凝胶，使用改良的Ｆｒａｎｚ 扩散池，进行体外释药试验。结果：发现凝胶剂中加入适量ＰＶＰ既可增加凝胶的粘结力，又可在一定范围内控制释药速率。结论：可供丹参酮外用贴剂研究提供帮助。Objective: To study the drug releasing properties of gel containing Tanshinone. Methods: The hydrophilic gels of containing Tanshinone were prepared to take Carbomer, hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) as base materials. The drug releasing experiments in vitro were carried out in improved Franz diffuser. Results: With the addition and amount of PVP into the gels, the stickiness of gels was increased and the drug releasing rates were controlled over a suitable rate range. Conclusion: The method may be used in the research of external paste containing Tanshinone.

关 键 词：丹参酮 释药速率 中药 凝胶剂 释药性 

分 类 号：R285[医药卫生—中药学]