唑吡坦对小鼠镇静催眠与抗惊厥半数有效量的研究  

The ED50 of zolpidem in the actions of hypnosis and anticonvulsion in rats

作　　者：李萍[1] 梁煜霞[1] 

机构地区：[1]广东省中医院二沙分院药剂科,广州510105

出　　处：《国际医药卫生导报》2011年第23期2867-2869,共3页International Medicine and Health Guidance News

摘　　要：目的测定唑吡坦对小鼠镇静催眠与抗回苏灵所致惊厥的半数有效量（E13so）。方法利用序贯法测定唑毗坦的半数有效量，然后利用丙二醛（MDA）试剂盒进一步确定唑吡坦抗惊厥的半数有效量。结果唑吡坦对小鼠镇静催眠半数有效量及其相对应的95％可信区间分别为0．08480mg／g及0．06761。0．10377mg／g；唑吡坦对小鼠抗回苏灵所致惊厥半数有效量及其相对应的95％可信区间分别为0．14257mg／g及0．12776～0．15658mg／g。结论唑吡坦对小鼠镇静催眠半数有效量和抗回苏灵所致惊厥半数有效量及其相对应的95％可信区间分别为0．08480mg／g及0．06761～0．10377mg／g和0．14257mg／g及0．12776～0．15658mg／g。Objective To determine the median effective dose （ED50） of zolpidem in the actions of hypnosis and anticonvulsion in rats. Methods The sequential method was used to detect the ED50 of zolpidem, and then the MDA assay kit was applied to further confirm the ED50 in the action of anticonvulsion. Results The EDso of zolpidem in the action of hypnosis was 0.084 80 mg/g and its 95% confidence interval（ CI ）was 0.067 61-0.103 77 mg/g, and in the action of anticonvulsion was 0.142 57 mg/g and its 95% CI was0.127 76 - 0.156 58 mg/g. Conclusions The ED50 of zolpidem in the actions of hypnosis and anticonvulsion and their 95% confidence interval are 0.08480 mg/g and 0.067 61 - 0.103 77 mg/g, and 0.142 57 mg/g and 0.127 76 - 0.156 58 mg/g, respectively.

关 键 词：唑吡坦 半数有效量 镇静催眠 惊厥 

分 类 号：R9[医药卫生—药学]