生脉成骨胶囊对激素性股骨头坏死髋周间充质细胞增殖的影响  

Effects of Shengmai Chenggu Capsules on Proliferation of Mesenchymal Stem Cells around Hip Joint in Rats with Steroid-Induced Avascular Necrosis of Femoral Head

作　　者：李保林 熊平[2] 庾伟中 贺华勇 叶勇光 王剑文 

机构地区：[1]广东省广州市正骨医院,广东广州510045 [2]华南农业大学,广东广州510642

出　　处：《安徽中医学院学报》2011年第6期47-50,共4页Journal of Anhui Traditional Chinese Medical College

基　　金：广东省科技计划项目(93087);广州市越秀区科技计划项目(2010-WS-001)

摘　　要：目的观察生脉成骨胶囊对激素性股骨头缺血性坏死大鼠股骨和髂骨间充质干细胞增殖及成骨细胞矿化结节生成的作用。方法将60只SD雄性大鼠随机分为6组:空白对照组、模型组、生脉成骨预防组、阿仑磷酸钠治疗组、丹郁骨康治疗组、生脉成骨治疗组,通过测定骨髓间充质细胞的增殖能力、成骨细胞矿化结节数,观察生脉成骨胶囊对股骨和髂骨近端成骨能力的影响。结果生脉成骨胶囊组股骨、髂骨骨髓间充质干细胞向成骨细胞转化增殖的水平和股骨、髂骨成骨细胞矿化结节数明显高于模型组,且生脉成骨预防组髂骨上述指标显著高于其他治疗组。结论生脉成骨胶囊能促进股骨、髂骨骨髓间充质细胞向成骨细胞转化增殖及促进矿化结节形成,从而促进激素性股骨头缺血性坏死模型大鼠成骨。Objective To research the effects of Shengmai Chenggu Capsules（SCC）,a traditional Chinese prescription,on the osteogenesis of mesenchymal stem cells and the mineralization nodus formation of osteoblasts of iliac bone and femur in rats with steroid-induced avascular necrosis of femoral head（SANFH）.Methods Sixty SD male rats were randomly divided into 6 groups：normal control group,model group,SCC prevention group,Alendronate treated group,Danyu Gukang（a patent traditional Chinese medicine） treated group and SCC treated group.The effects of SCC on the osteogenesis of the proximal ilium and femur were observed by determining the proliferation of mesenchymal stem cells and the number of mineralization nodus.Results The transformation and proliferation levels of mesenchyma stem cells and the number of mineralization nodus in femur and iliac bone were significantly higher in SCC prevention group than those in the model group.Furthermore,the above-mentioned indicators in SCC prevention group were significantly higher than those in other treatment groups.Conclusion SCC can promote the proliferation of mesenchymal stem cells and the mineralization nodus formation of femur and iliac bone,which is in favor of the osteogenesis in SANFH rats.

关 键 词：股骨头坏死 生脉成骨胶囊 间充质细胞 增殖 成骨 

分 类 号：R681.8[医药卫生—骨科学]