强心复脉颗粒对兔慢性窦房结损伤模型心律的影响  

Effect of Qiangxin Fumai Granule on Cardiac Rhythm of Sinoatrial Node with Chronic Injury in Rabbits

作　　者：刘如秀[1] 王妮娜[1,2] 李汇博[2] 暴美静[2] 汪艳丽[2] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029

出　　处：《中国中医药信息杂志》2011年第12期34-35,38,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(30873332)

摘　　要：目的在建立兔慢性窦房结损伤模型的基础上,观察强心复脉颗粒方对该模型的影响。方法大耳白兔30只,随机分为正常组、模型组、阿托品组及强心复脉颗粒高、中、低剂量组(以下简称高、中、低剂量组),每组5只,正常组不造模,余5组甲醛加压注射渗透法建立兔慢性病态窦房结综合征模型,并于模型建立稳定后连续灌胃给药7 d,分别观测各组造模及给药前后心律的变化。结果与正常组比较,模型组、阿托品组及高、中、低剂量组造模后心率均明显降低(P<0.01)。与模型组比较,阿托品组及高、中、低剂量组给药后心率均有不同程度升高(P<0.05或P<0.01)。且高剂量组较西药阿托品组效果显著(P<0.05),低、中剂量组与阿托品组比较无统计学意义(P>0.05)。结论强心复脉颗粒能够提高心率、改善心律失常,对病态窦房结综合征有一定的治疗作用。Objective To study the effect of Qiangxin Fumed granule on cardiac rhythm of the sinoatrial node with chronic injury in rabbits. Methods Sixty healthy adult big ears white rabbits were randomly divided into 6 groups： the normal group, the model group, the atropine group, the high-dose Qiangxin Fumai Granule group, the middle-dose Qiangxin Fumai Granule group and the low-dose Qiangxin Fumai Granule group, with five animals in each group. The rabbit model was established by injecting formaldehyde to the sinoatrial node except the normal group. After the model established, the rabbits received intragastric administration for 7 days, the changes of heart rate at different phases were measured. Results Compared with the normal group, the heart rate in the model group, the atropine group, the high-dose Qiangxin Fumai granule group, the middle-dose Qiangxin Fumai Granule group and the low-dose Qiangxin Fumai granule group were slowed significantly （P〈0.05 or P〈0.01）. Compared with the model group, the heart rate in four treatment groups was accelerated significantly, and the high-dose Qiangxin Fumai Granule group was superior to the atropine group （P〈0.05）. Conclusion Qiangxin Fumai granule can accelerate the heart rate and is beneficial for recovery of sinus node function so as to treat the sick sinus syndrome.

关 键 词：强心复脉颗粒 慢性窦房结损伤 病态窦房结综合征 兔 

分 类 号：R285.5[医药卫生—中药学]