心力衰竭并恶液质患者血清脂联素水平与BMI、脑钠肽的关系  

Corelation of serum adiponectin and BMI and BNP in patients with heart failure and cachexia

作　　者：周南南[1] 卓晶明[1] 东燕[1] 李春梅[1] 

机构地区：[1]山东大学附属省立医院,济南250021

出　　处：《山东医药》2011年第45期21-22,共2页Shandong Medical Journal

基　　金：山东省自然科学基金资助项目(Y2006c130)

摘　　要：目的探讨心力衰竭(HF)并恶液质患者血清脂联素(ADP)水平与BMI、脑钠肽(BNP)的关系。方法将80例心血管病患者分为三组,A组20例有冠心病(CHD)、HF并恶液质;B组40例有CHD史、HF,无恶液质;C组20例有CHD,无HF。另选14例查体健康者作为对照组。检测各组血清ADP、BNP、左室射血分数,计算其BMI;分析ADP水平与BMI、BNP的相关性。结果 A组血清ADP、BNP明显高于其他三组(P均<0.01),其ADP水平与BMI呈负相关(r=-0.47,P<0.01),与BNP呈正相关(r=0.55,P<0.01)。结论 HF并恶液质患者血清ADP明显升高,提示ADP水平与HF患者发生恶液质有因果关系;ADP水平与BNP呈正相关,提示BNP可能促进血清ADP分泌。Objective To study the association of adiponectin concentration in patients with heart failure（HF） and cachexia with body mass index（BMI） and B-type natriuretic peptide（BNP）.Methods A total of 80 patients with coronary artery disease（CHD） were included into 3 groups： group A（HF and cachexia,n=20）,group B（HF without cachexia,n=40）,group C（no HF,n=20）;and a control group of 14 healthy persons were studied as well.BMI were calculated and adiponectin,BNP and LVEF were tested for all subjects.The associations of ADP with BMI and BNP were studied.Results Patients with HF and cachexia had higher concentrations of adiponectin and BNP than the other groups.Adiponectin was correlated negatively with BMI,and positively with BNP.Conclusion Cachexia in HF is associated with an increase in adiponectin concentration.This may indicate a possible ＂cause and effect＂ relationship between increased adiponcetin concentration and cachexia in HF.The positive correlation between BNP and adiponectin also raises the possibility that the former might increase the secretion of the latter.

关 键 词：心力衰竭 恶液质 脂联素 脑钠肽 体质量指数 

分 类 号：R541[医药卫生—心血管疾病]