氟哌啶醇对氯胺酮所致小鼠条件性位置偏爱的影响  

Impact of Haloperidol on Conditional Place Preference Induced by Ketamine in Mice

作　　者：丁晓维[1] 史兰芃[1] 蒋道猛[1] 徐小艳[1] 周涵[1] 戚灿[1] 熊振天[1] 马涛[2] 

机构地区：[1]徐州医学院麻醉学院2007级1班,221004 [2]徐州医学院麻醉药理学教研室,221004

出　　处：《医药导报》2011年第12期1546-1548,共3页Herald of Medicine

基　　金：江苏省高校自然科学基础研究基金资助项目(基金编号:09KJB320019);宁波市自然科学基金资助项目(基金编号:2009A610140)

摘　　要：目的观察氟哌啶醇对氯胺酮诱导的小鼠条件性位置偏爱的影响。方法受试小鼠40只,随机分为4组,每组10只:0.9%氯化钠注射液组(NS组),氯胺酮组(K组),氯胺酮+0.33 mg.kg-1氟哌啶醇组(KH1组)和氯胺酮+1.0 mg.kg-1氟哌啶醇组(KH2组)。各组小鼠分别接受条件性位置偏爱实验,观察分析受试小鼠用药前后在白箱停留的时间。结果 NS组、K组、KH1组和KH2组白箱停留时间基础值分别为(157.38±68.75)(,197.78±90.16)(,190.11±127.47)(,244.00±127.88)s,戒断24 h后分别为(316.25±263.52)(,337.44±152.92)(,324.44±172.61)(,317.56±165.85)s;与基础值相比,K、KH1组戒断24 h后有精神依赖作用(P<0.05),KH2组戒断24 h后无明显的精神依赖作用(P>0.05)。结论氟哌啶醇可干扰氯胺酮所致小鼠的条件性位置偏爱,提示其可能有减弱氯胺酮精神依赖性的作用。Objective To investigate the effects of haloperidol（H） on conditional place preference induced by ketamine（K） in mice. Methods Forty mice enrolled were randomly divided into 4 groups（n= 10）：control group（NS group）,ketamine group（K group）,ketamine plus haloperidol（0.33 mg·kg-1） group（KH1 group） and ketamine plus haloperidol（1.0 mg·kg-1） group（KH2 group）.The conditional place preference（CPP） tests were carried out in each mouse and the duration of staying in the white box 24 hours before and after withdrawal. Results The basic duration for 24 hours before withdrawal in group NS,K,KH1 and KH2 was（157.38±68.75）,（197.78±90.16）,（190.11±127.47） and（244.00±127.88） s,respectively;that for 24 hours after withdrawal was（316.25±263.52）,（337.44±152.92）,（324.44±172.61）and（317.56±165.85） s,respectively.Compared with the basic duration within group,the duration of staying in the white box after withdrawal for group K or group KH1 prolonged（P0.05）,but no statistically significant difference（P0.05） was found for group KH2. Conclusion Haloperidol may interfere with the conditional place preference induced by ketamine in mice,which implies that it may lessen the psychic dependence caused by ketamine.

关 键 词：氟哌啶醇 氯胺酮 位置偏爱 条件性 精神依赖性 小鼠 

分 类 号：R971.4[医药卫生—药品] R965[医药卫生—药学]