芥子气软膏治疗豚鼠银屑病样皮损的作用机制  

Therapeutic Mechanism of Sulfur Mustard on Guinea Pigs with Psoriasis-like Skin Lesions

作　　者：杨积顺 徐立平 胡晋红[2] 

机构地区：[1]解放军第100医院药械科,苏州215007 [2]第二军医大学上海长海医院药学部,200433

出　　处：《医药导报》2011年第12期1562-1564,共3页Herald of Medicine

摘　　要：目的探讨芥子气软膏对豚鼠银屑病样皮损的治疗机制。方法豚鼠耳廓均匀涂抹5%普萘洛尔乳膏,bid,持续28 d。从第21天起,再给予芥子气软膏。测量豚鼠耳廓厚度,苏木精-伊红(HE)染色、组织学评分以及免疫组织化学法检测用药前后肿瘤坏死因子相关凋亡诱导配体(TRAIL)的表达变化。结果芥子气软膏可降低豚鼠银屑病样皮损耳廓肿胀度(P<0.05),病理组织切片可见皮肤组织逐渐恢复正常,与对照组相比,经芥子气软膏治疗后,皮肤基底层和棘层TRAIL蛋白强阳性表达。结论芥子气软膏治疗银屑病的作用机制可能与诱导TRAIL蛋白的过度表达及促进表皮变异细胞的凋亡有关。Objective To explore the therapeutic mechanism of sulfur mustard（SM）on guinea pigs with psoriasis-like skin lesions. Methods 5% propranolol cream was evenly applied on ears of guinea pigs twice a day for 28 d.Since day 21 guinea pigs were co-treated with sulfur mustard paste.The thickness of guinea pig＇s ears was tested,and skin pathological changes were detected by HE staining.The expression level of TRAIL was determined by immunohistochemical staining. Results Sulfur mustard ameliorated ear swelling of guinea pigs（P0.05）.It reversed the injured skin to normal and promoted the TRAIL expression in sera conspicuously vs the control group. Conclusion Therapeutic mechanism of sulfur mustard for psoriasis could be related to inducing over-expression of TRAIL,and promoting apoptosis of skin mutant cells.

关 键 词：芥子气软膏 普萘洛尔乳膏 银屑病 肿瘤坏死因子相关凋亡诱导配体 

分 类 号：R986[医药卫生—药品] R965[医药卫生—药学]