抗HIV抑制剂cyanovirin-N的研究进展  

Progress in research of the anti-HIV inhibitor cyanovirin-N

作　　者：李斯文[1] 顾觉奋[1] 

机构地区：[1]中国药科大学生命科学与技术学院,南京210009

出　　处：《中国新药杂志》2011年第23期2326-2329,2339,共5页Chinese Journal of New Drugs

摘　　要：Cyanovirin-N(CV-N)是一种天然蛋白,由蓝细菌合成分泌,低浓度(0.1～36.8 nmol.L-1)能有效抑制HIV感染免疫细胞,高浓度(45～400 nmol.L-1)对正常细胞无直接的毒副作用。CV-N是作用于吸附过程的HIV抑制剂并且作为局部用(阴道、直肠等)抗HIV药物正处于临床前开发阶段。本文对Cyanorivin-N的理化性质、结构和抗病毒作用机制等进行了概述。Cyanovirin-N （CV-N） is a protein derived from the cyanobacterium nostoc ellipsosporu. CV-N can effectively inhibit HIV infection of immune cells at low concentrations （0.1 -36.8 nmol·L^-1） , and has no direct side-effects on normal cells at high concentrations （45 - 400 nmol·L^-1 ）. CV-N is active in the adsorption process of HIV inhibitors, and as a local （ such as vaginal and＇rectal tracts） anti-HlV drug has been in preclinical development. The structure, physical-chemical property and the antiviral mechanism of CV-N were summarized. The compound is an inhibitor of HIV, but also found to inhibit other enveloped viruses.

关 键 词：cyanovirin—N 获得性免疫缺陷综合征 抗病毒活性 

分 类 号：R978.7[医药卫生—药品]