聚乳酸膜和脱钙冻干胚胎骨促进骨修复的比较研究  

A Comparative Study of Promoting Bone Healing by PLA Membrane and Demineralized Freeze-Dried Fetal Bone.

作　　者：侯劲松[1] 李祖兵[1] 

机构地区：[1]湖北医科大学口腔医学院颌面外科,武汉430070

出　　处：《临床口腔医学杂志》1999年第4期205-207,共3页Journal of Clinical Stomatology

摘　　要：目的　比较聚乳酸 ( PLA)膜和脱钙冻干胚胎骨 ( Fetal Bone,FB)促进骨修复的能力。方法　在 12只日本大耳白兔双侧下颌骨下缘中份作方块切除形成骨缺损 ,一侧缺损植入 FB,另一侧缺损表面覆盖 PLA膜。术后 4、8、12周分期处死动物 ,下颌骨标本行放射学和组织学观察。结果　两种材料均能有效修复骨缺损。FB植入 4W后术区内有大量新骨形成 ,术后 8W缺损内骨形成活跃程度和骨形成量均高于 PLA膜侧。结论　 FB植入后骨缺损内骨修复启动早 ,成骨活跃 ,用于颌骨缺损修复较 PL A膜理想。Objective To compare the effection of PLA membrane and demineralized freeze-dried fetal bone on promoting bone formation. Materials and Methods Bilateral mandibular defects were created in twelve adult rabbits.Left defects were filled with FB,and the right defects were covered by PLA membranes.Animals were sacrified at 4,8,12 weeks after operation.The mandible specimens were assessed by radiograph and light macroscopy. Results Newly-formed bone in left bone defect was greater than those in right defect at each stage. Conclusion This study indicates that FB is the more preferable material for repairing mandibular defect.

关 键 词：胚胎骨 聚乳酸膜 骨修复 骨移植 

分 类 号：R687.3[医药卫生—骨科学]