血清胱抑素C测定在毛细支气管炎中的临床意义  

Clinical significance of cysteinyl cystatin C detection in bronchiolitis

作　　者：吴祖成 陈玉 李建安 鄢能荣 宋柳安 陈志新 尹俊 林世光 

机构地区：[1]广东省深圳市石岩人民医院儿科,广东深圳518108

出　　处：《安徽医药》2011年第12期1546-1547,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的通过测定毛细支气管炎患儿血清胱抑素C、血尿素氮、血肌酐的含量,探讨毛细支气管炎患儿肾功能的变化。方法对50例毛细支气管炎(重症18例,轻型32例)患儿急性期、缓解期、25例健康对照组分别测定血清胱抑素C、血尿素氮、血肌酐水平,并将三组测定结果进行对比分析。结果重型组急性期血清胱抑素C值与缓解期、正常对照组比较明显升高(P<0.05),重型缓解期与轻型组、正常对照组血清胱抑素C比较无明显升高,三组血尿素氮、血肌酐之间比较差异无统计学意义。结论重型毛细支气管炎患儿急性期存在一过性肾损害;血清胱抑素C与血尿素氮、血肌酐比较,是早期诊断肾脏损害更敏感的指标。Aim To explore changes in renal function for children suffering from bronchiolitis by determining the content of serum cystatin C.Methods 50 cases of children suffering from bronchiolitis were selected as experiment group and 25 healthy children as controls.Then content of serum cystatin C,urea nitrogen and serum creatinine were determined.Finally,the results of the controls,the experiment group in acute and remittent stage were compared.Results The content of serum cystatin C in experiment group in acute stage had a significant increase compared with that in remittent stage as well as in control group（P〈0.05）.The content of serum cystatin C in experiment group in remittent stage had no obvious change compared with that in moderate group and the control group.The comparison between the content of blood urea nitrogen and serum creatinine among three groups also had no statistical significance（P〈0.05）.Conclusion There exists acute kidney injury for children suffering from severe acute bronchiolitis.Compared with blood were nitrogen and serum creatinine serum cystatin C is a more sensitive indicator for the diagnosis of kidney damage in the early stage.

关 键 词：毛细支气管炎 血清胱抑素C 急性肾脏损害 

分 类 号：R725.6[医药卫生—儿科]