莓茶乙醇提取物的急性毒性研究  

Study on acute toxicological evaluation of ethanol extracts from fusty tea

作　　者：谭平[1] 姚茂君[2] 辛益妹[3] 马美湖[2] 

机构地区：[1]湖南机电职业技术学院,湖南长沙410151 [2]华中农业大学食品科学技术学院,湖北武汉430070 [3]中国人民解放军空军航空医学研究所,北京100036

出　　处：《食品与机械》2011年第6期101-102,106,共3页Food and Machinery

基　　金：国家星火计划项目(编号:2006EA770049);湖南省自然科学基金资助项目(编号:06JJ5019);湖南省教育厅高校科研项目(编号:11C0475)

摘　　要：对莓茶乙醇提取物的急性毒性进行研究。取Wistar大鼠40只,清洁级,随机分为2组,每组20只,雌雄各半,以最大耐受量法灌胃给予受试样品组大鼠最大使用浓度和最大灌胃容量的莓茶乙醇提取物,1天2次(相隔4h),连续观察14d。结果表明,受试样品组大鼠毛色,皮肤,粘膜,眼睛,呼吸,循环,自主活动及中枢神经系统、行为表现等均与阴性对照组大鼠无明显差别,整个试验期内无大鼠死亡,莓茶乙醇提取物大鼠口服灌胃的最大耐受量为10.0g/kg大鼠体重;对所有试验大鼠进行大体解剖,组织器官未见有颜色、体积、质地等改变,说明莓茶乙醇提取物的毒性很小,具有较好的食用安全性。The acute toxicological evaluation was studied of ethanol extracts from fusty tea（Ampelopsis grossedentata）.The rats were given the ethanol extracts from fusty tea with the maximum concentration and capacity by gastric perfusion,twice a day,for 14 days.The result showed that compared with Wistar control group,there were no abnormal reactions during the observation period on skin,mucosa,coat color,eyes,breath,circulation,locomotor activity,central nervous system,behavior etc.in Wistar sample group,without rats＇ death,and the maximum tolerance was 10.0g/kg by gastric perfusion.There were no change in the tissues and organs on volume,color and texture,which showed the extracts were low toxic and are better safe to eat.

关 键 词：莓茶 显齿蛇葡萄 二氢杨梅素 急性毒性 

分 类 号：R285.5[医药卫生—中药学]