罗库溴铵靶控输注用于老年患者腹腔镜手术效果观察  

Efficacy of rocuronium for target controlled infusion system in geriatric patients operation on laparoscopic surgery

作　　者：牟林[1] 

机构地区：[1]重庆市肿瘤研究所,400030

出　　处：《检验医学与临床》2011年第23期2832-2833,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨罗库溴铵靶控输注(TCI)用于老年患者腹腔镜手术的效果。方法择期行腹腔镜手术老年患者84例,美国麻醉医师协会(对患者的病情和体格情况评估标准)(ASA)Ⅱ级,年龄65～83岁,随机分为A、B、C 3组,每组28例,将A、B、C 3组诱导插管时静脉注射罗库溴铵0.6mg/kg,术中维持效应室靶浓度分别为0.6、0.8、1.0mg/L。观察各组诱导插管起效时间、气管插管条件、术中骨骼肌松弛条件和术后骨骼肌松弛恢复情况。结果 A、B、C 3组均可顺利完成气管插管,术中A组骨骼肌松弛条件满意率低于B组和C组;与B组比较,C组罗库溴铵用药量大,术中肌肉阻滞程度较深,术后恢复时间延长,差异有统计学意义(P<0.05)。结论老年患者腹腔镜手术诱导插管时以罗库溴铵0.6mg/kg进行骨骼肌松弛维持,术中效应室靶浓度维持在0.8mg/L,可以实现诱导插管顺利、术中骨骼肌松弛满意和术毕迅速恢复。Objective To investigate the efficacy of rocuronium for target controlled infusion in geriatric patients operation on laparoscopic surgery.Methods 84 ASA grade Ⅱ and 65-83 years aged geriatric patients scheduled for operation on laparoscopic surgery under general anesthesia were randomized into A,B,C three groups,with 28 patients in each group.Rocuronium for intubation was 0.6 mg/kg in each group,and the target effective site concentration（Ce） during operation were 0.6 mg/L,0.8 mg/L,and 1.0 mg/L in A,B and C group,respectively.Results Successful intubation condition was obtained in three groups.Neuromuscular block during operation was satisfactory in group B and C,but not in group A.The rocuronium consumption,muscle relaxation during surgery and recovery time to 25% of T1 of C group were more than those of group B（P0.05）.Conclusion The dosage regimen of group B（0.6 mg/kg of rocuronium for maintaining skeletal muscle relaxation during intubation,and 0.8 mg/L of the target effective site concentration during operation）is more suitable for geriatric patients operation on laparoscopic surgery.

关 键 词：老年患者 靶控输注 罗库溴铵 腹腔镜手术 

分 类 号：R656[医药卫生—外科学]