非糖尿病患者糖化血红蛋白与冠状动脉狭窄之间的关系  

The relationship between the glycated hemoglobin and coronary stenosis in non-diabetic patients

作　　者：刘瑛琪 费军[2] 贾付坤 刘莉 王晓非 高铁山 张朝利[2] 

机构地区：[1]解放军第三○六医院心内科,北京100101 [2]解放军第三○六医院放射科,北京100101

出　　处：《中国临床保健杂志》2011年第6期580-582,共3页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨非糖尿病患者糖化血红蛋白与冠状动脉狭窄之间的关系。方法 264例因胸痛行双源CT冠状动脉造影的患者,均行糖化血红蛋白(HbA1c)检查,根据HbA1c值将患者分为HbA1c≤5.5%组和5.5%<HbA1 c<6.5%两组,比较两组间冠状动脉狭窄程度和范围的差异。结果 5.5%<HbA1 c<6.5%组的患者更多发生中及重度狭窄,两组患者间单支及双支以上病变的发生率也有显著差异(P<0.05)。结论非糖尿病患者中糖化血红蛋白值升高是冠心病的危险因素。Objective To explore the relationship between the value of glycated hemoglobin（HbA1c）and coronary stenosis in non-diabetic patients.Methods 264 cases of patients who received the CT angiography because of chest pain.All the patients had accepted the test of HbA1c.The patients were divided into 2 groups according to the HbA1c level,namely HbA1c≤ 5.5% group and 5.5%HbA1c6.5% group.The extent and severity of coronary stenosis were compared between these two groups.Results Compared with the control group,there were more cases of median or severe coronary stenosis in the 5.5%HbA1c6.5% group.There was also a significant difference between these two groups in the occurrence of single and multivessel coronary lesion.Conclusion Higher HbA1c may be a risk indicator of coronary artery disease in non-diabetic patients.

关 键 词：冠状动脉狭窄 血红蛋白A 糖基化 冠心病 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]