高温与电离辐射对胎鼠脑核酸、蛋白质的影响  

Combined Effects of Heat and Ionizing Radiation on Nucleic Acid and Protein of Embryonic Brains of Mice

作　　者：阮明[1] 芦春林[1] 杨业鹏[1] 洪敏 

机构地区：[1]北京医科大学,北京市100083

出　　处：《工业卫生与职业病》1999年第6期338-340,共3页Industrial Health and Occupational Diseases

摘　　要：为探索高温和电离辐射对胎脑的影响， 用孕第９ 天小鼠给予４２ ℃和１－０ Ｇｙ 处理，孕第１８ 天取胎脑， 测量ＤＮＡ、ＲＮＡ 和蛋白质含量。结果表明， １－０ Ｇｙ 照射组、照射＋ ４２ ℃组与对照组比， 胎脑核酸和蛋白质有明显减少。４２ ℃＋ 照射组与４２ ℃组比， 胎鼠脑核酸和蛋白质含量没有显著性变化。提示辐射可引起胎脑核酸、蛋白质含量减少， 预先４２ ℃１０ 分钟处理孕鼠， 随后再给较大剂量电离辐射的照射，In order to study if heat and ionizing radiation could produce combined effects on embryonic brains of mice,the mice with gestation of 9 days were exposed to temperature of 42 ℃ and 1 0 Gy 60 Co γ rays.The value of DNA,RNA and protein of embryonic brains of mice was measured on the 18th day of gestation.Results showed that values of nucleic acid and protein of embryonic brains of mice of the 1 0 Gy group and 1 0 Gy and 42 ℃ temperature group were lower than those of the control.However,theres no significant difference between these two groups.It could be concluded that 1 0 Gy 60 Co γ rays ionizing radiation could reduce the value of nucleic acid and protein of embryonic brains of mice.Preexposure to the temperature of 42 ℃ for 10 mins followed by 1 0 Gy 60 Co γ rays radiation could induce cross adaptive response of embryonic brain of mice.

关 键 词：电离辐射 高温 胎鼠 脑发育 DNA RNA 蛋白质 

分 类 号：R715.3[医药卫生—妇产科学] R131[医药卫生—临床医学]