二硫化碳作业女工早期胚胎损伤的剂量反应关系  

DOSE RESPONSE RELATIONSHIP BETWEEN THE EXPOSURE LEVELS TO CARBON DISULPHIDE AND THE RATES OF TIME TO PREGNANCY OR AND THE RATE OF VERY EARLY PREGNANCY LOSS FOR OCCUPATIONAL WOMEN

作　　者：韩连堂[1] 王志萍[1] 张呈祥 李佩贤[1] 侯光萍[3] 杜继胜 邱玉刚[1] 王崇伟 任永清[3] 洪舜华[1] 

机构地区：[1]潍坊医学院卫生学教研室,潍坊261042 [2]潍坊市化纤厂职工医院 [3]潍坊市人民医院

出　　处：《潍坊医学院学报》1999年第4期253-255,共3页Acta Academiae Medicinae Weifang

摘　　要：目的　探讨女工二硫化碳（ＣＳ２）接触水平与胚胎早期发育障碍之间的剂量－ 反应关系。方法　前瞻观察欲生育女工妊娠所需的月经周期数；收集每个月经周期胚胎植入期尿样，检测绒毛膜促性腺激素含量；监测女工作业地点ＣＳ２ 浓度。结果　２５７ 名接触组经临床确诊妊娠的女工，各月经周期妊娠机率低于 ３６６ 名对照组女工，时间妊娠率随女工ＣＳ２ 接触水平（ＣＳ２ 接触浓度乘以ＣＳ２ 接触工龄）升高而降低：妊娠率＝ ０．７０３３－ ０．００１５×接触水平（χ２＝ ６４．７１，Ｐ＝ ０．０００；ｒ＝ － ０．９７９，Ｐ＝ ０．０００）；检测３４０ 个月经周期尿样早早孕丢失，接触组女工早早孕丢失率明显高于对照组，早早孕丢失率随女工ＣＳ２ 接触水平升高而增加：丢失率＝ ０．４７１７＋ ０．００２８×接触水平（χ２＝ ２５．５９，Ｐ＝ ０．００１；ｒ＝ ０．９７７，Ｐ＝ ０．０００），均呈现出明显的剂量－ 反应关系。结论　随着女工ＣＳ２ 接触水平的增高，早早孕丢失率明显增加，使每个月经周期妊娠率降低，呈现出明显的剂量－ 反应关系，表明ＣＳ２ 对胚胎早期发育的损伤作用具有蓄积性。Objective To detect the dose response relationship between the exposure levels(EL) to carbon disulphide (CS 2) and the rates of time to pregnancy or and the rates of very early pregnancy loss in occupational women.Method Following up how many cycles would be used to get a clinically identified pregnancy for each woman who attempted to have a baby,collecting daily urine samples at implantation for measuring the level of human chorionic gonadotropin while menstruations and clinical pregnancy was traced and monitoring the concentrations of CS 2 in her working spot.Result When the exposure levels(EL,the concentrations of CS 2 multiplied by years of exposure) went up,the rates of time to pregnancy (RP) went down.The relation between RP for first six menstrual cycles and the EL was RP=0.7033-0.0015EL (χ 2=64.71,P=0.000;r=-0.979,P=0.000).When the EL rised,the rate of very early pregnancy loss ( RL) became higher.The relation between RL and EL was RL=0.4717+0.0028EL (χ 2=25.59,P=0.001;r=0.977,P=0.000).Conclusion It was shown that there were dose relationship between EL to CS 2 and RP or and RL,and it was shown that along with the rising of EL,accumulation toxicity on early embryoes development appeared.

关 键 词：生殖损伤 妊娠时间 早早孕丢失 二硫化碳 

分 类 号：R131[医药卫生—劳动卫生] R714.21[医药卫生—公共卫生与预防医学]