磁共振弥散加权成像评价肝硬化程度的初步研究  

Preliminary study of MR diffusion weighted imaging in evaluating the degree of liver cirrhosis

作　　者：史东立[1] 李宏军[1] 

机构地区：[1]首都医科大学附属北京佑安医院放射科,北京100069

出　　处：《磁共振成像》2011年第6期413-415,共3页Chinese Journal of Magnetic Resonance Imaging

基　　金：北京卫生系统高层次卫生技术人才培养计划项目(编号:2009-3-55)资助

摘　　要：目的探讨肝脏弥散加权成像表观弥散系数值(apparent diffusion coefficients,ADC)评价肝硬化患者肝功能的临床应用价值。方法对95例受检者行DWI检查,正常对照组35例,肝硬化组60例,其中Child-Pugh分级A级、B级28例,为肝硬化AB组,Child-Pugh分级C级32例,为肝硬化C组。测量所有受检者肝脏ADC值,比较三组间ADC值差异。结果正常对照组肝脏ADC值为(1.28±0.14)×10-3mm2/s,肝硬化AB组和C组ADC值分别为(1.18±0.17)×10-3mm2/s和(0.91±0.34)×10-3mm2/s,肝硬化AB组和正常对照组无统计学差异(P=0.069),肝硬化C组和肝硬化AB组、肝硬化C组和正常对照组比较差异有统计学意义(P=0.000,P=0.000)。结论肝硬化患者肝纤维化程度越重,ADC值越小。ADC值在一定程度上能够反映肝硬化程度。Objective： To investigate the value of MR diffusion weighted imaging （DWI） in patients with liver cirrhosis. Materials and Methods： Ninety-five cases （35 healthy volunteers and 60 patients with liver cirrhosis） were recruited with their apparent diffusion coefficients （ADC） of liver analyzed. According to liver Child-Pugh classification, 60 patients with liver cirrhosis were classified into group AB （28 cases） and group C （32 cases） with their ADC measured and compared intra-group and with that of the volunteers. Results： The ADC values of the control group, group AB and group C were （1.28±0.14）×10-3 mm2/s, （1.18±0.17）×10-3 mm2/s, and （0.91±0.34）×10-3 mm2/s, respectively. The difference was significant between group C and group AB and group C and control group （P=0.000, P=0.000）, respectively. There was no statistical significance between group AB and control group （P=0.069）. Conclusions： The value of ADC decreased as the aggravation of the hepatic cirrhosis. To some extent, the ADC value may reflect the degree of liver cirrhosis.

关 键 词：磁共振成像 肝硬化 弥散加权成像 CHILD-PUGH分级 

分 类 号：R445.2[医药卫生—影像医学与核医学] R657.31[医药卫生—诊断学]