肾小球疾病患儿24小时尿锌铜含量变化研究  

Clinical significace of 24hour urinary zinc and copper in children with glomerular disease

作　　者：高岭[1] 郁飞[1] 王均乐[1] 

机构地区：[1]南京医科大学附属南京儿童医院检验科,江苏南京210008

出　　处：《西部医学》2011年第12期2423-2425,共3页Medical Journal of West China

摘　　要：目的探讨肾小球疾病患儿尿中24小时尿锌、铜的含量变化以及肾小球疾病损伤程度与尿锌、铜变化的关系。方法采用电感耦合等离子体原子发射光谱ICP-AES法测定42例肾小球损伤患儿以及65例正常对照组24小时尿锌、铜含量。结果肾小球损伤患儿尿锌、铜含量与对照组之间有显著差异(P<0.05),肾小球疾病尿蛋白电泳两条带以上组较两条带组之间尿锌、铜有显著差异(P<0.05)。结论 24小时尿铜、锌在肾小球疾病时排除量明显增加,尿锌、铜的含量可作为肾小球损伤的辅助诊断标准,同时提示补充和调整微量元素对肾小球损伤患儿有一定意义。Objective To measure the total 24hour urinary zinc and urinary copper in children with glomerular disease and to investigate the realationship between the concentration of urinary zinc and urinary copper and the injury degree of glomerular.Methods 42 children with glomerular disease and sixty-five age-matched healthy children were studied and measure the concentration of urinary zinc and urinary copper by inductively coupled plasma atomic emissionspectrometry（ICP-AES）.Results The levels of 24hour urinary zinc and urinary copper in children with glomerular disease was remarkably higher than that in age-matched healthy children（P〈0.05）.Furthermore,the levels of 24hour urinary zinc and urinary copper were different between the group of more than two bands and the group of only two bands in the protein electrophoresis tests（P〈0.05）.Conclusion The total 24hour urinary zinc and urinary copper in children with glomerular disease was increased remarkably,which can be used as auxiliary diagnostic criteria of glomerular injury and imply that adjusting the microelement may be helpful to the children with glomerular disease.

关 键 词：肾小球疾病 尿锌 尿铜 蛋白电泳 

分 类 号：R692.31[医药卫生—泌尿科学]