不同程度缺氧OSAHS患者前庭脊髓反射的观察  

Effects of different degree hypoxia on the vestibulospinal reflexes in patients with obstructive sleep apnea and hypoventilation syndrome

作　　者：皮丽宏[1] 郭明丽[1] 王荣国[1] 郑墨荣[1] 

机构地区：[1]河北省人民医院耳鼻咽喉科,石家庄市050051

出　　处：《河北医药》2011年第24期3692-3694,共3页Hebei Medical Journal

基　　金：河北省医学科学研究重点课题(编号:20100177)

摘　　要：目的对不同程度缺氧阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者进行静态姿势描记(PSG),观察不同程度缺氧对OSAHS患者前庭脊髓反射的影响。方法根据缺氧程度不同将98例OS-AHS患者分为3组:轻度组31例、中度组34例、重度组33例,选30例为对照组,分别行PSG,对33例重度组OSAHS患者行持续正压通气治疗(CPAP)前后PSG测试对比。结果 PSG各参数轻度组比较差异无统计学意义(P>0.05),中度组与对照组、轻度组比较差异有统计学意义(P<0.05),重度组与对照组、中度组、轻度组比较差异有统计学意义(P<0.01);OSAHS患者CPAP治疗3个月外周面积及路径总长较治疗前降低(P<0.05),其中晃动速度减低更为显著(P<0.01)。结论中、重度OSAHS患者的前庭脊髓反射功能下降,CPAP有助于改善OSAHS患者的前庭脊髓反射功能。Objective To observe the effects of different degree hypoxia on the vestibulospinal reflexes（VSR） in patients with obstructive sleep apnea and hypoventilation syndrome（OSAHS） by static posturography（PSG）.Methods A total of 98 patients with OSAHS were divided into 3 groups according to the degree of hypoxia,which were mild group（group B,n=31）,moderate group（group C,n=34）,severe group（group D,n=33）,and 30 volunteers were enrolled as control group（group A）.The parameters of PSG were measured respectively.The PSG parameters for 33 patients in group D were compared before and after treatment by continuous positive airway pressure（CPAP）.Results There were no significant differences in these parameters of static PSG between group B and group A（P〉0.05）,however,there were significant differences between group C and group A,group B（P〈0.05）,and there were significant differences between group D and the other three groups（P〈0.01）.After 3-month treatment by CPAP,the periphery area and total pathway length in 33 patients with severe OSAHS were significantly decreased,as compared with those before treatment（P〈0.05）,especially,the sway velocity was reduced much more obviously（P〈0.01）.Conclusion The VSR function in patients with mild or severe OSAHS is decreased,and CPAP contributes to improving the VSR function in patients with OSAHS.

关 键 词：睡眠呼吸暂停 阻塞性 静态姿势描记 前庭脊髓反射 连续气道正压通气 

分 类 号：R441.8[医药卫生—诊断学]