Prion-like behavior of MAVS in RIG-I signaling  

作　　者：Eva Marie Y Moresco Diantha La Vine Bruce Beutler 

机构地区：[1]Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA

出　　处：《Cell Research》2011年第12期1643-1645,共3页细胞研究（英文版）

摘　　要：Viral infection triggers the innate antiviral response in part through acti- vation of RIG-I, a cytoplasmic sensor of 5＇-triphosphorylated and uncapped single- or double-stranded RNA, which are not found among endogenous self- RNA. RIG-I signaling depends on the function of mitochondrial antiviral signaling （MAVS） protein, an adapter that links RIG-I, and the related RNA sensor MDA5, to events leading to transcriptional activation by NF-κB and IRF3. In contrast to the cytoplasmic localization of other innate immune signalin adapters,

关 键 词：朊病毒 双链RNA 信令 行为 信号蛋白 转录激活 病毒感染 先天免疫 

分 类 号：S852.659.7[农业科学—基础兽医学] Q522[农业科学—兽医学]