KAI1、MMP-9在子宫内膜异位症中的表达及意义  

KAI1, MMP9 in endometriosis sickness expression and significance

作　　者：张雪梅 马凤英 梁磊 丁玎 吴丽姝 卢美松 

机构地区：[1]哈医大五院妇产科,哈尔滨163000 [2]哈医大五院产房,哈尔滨163000 [3]哈医大一院妇产科 [4]不详

出　　处：《中国医师杂志》2011年第11期1473-1475,共3页Journal of Chinese Physician

摘　　要：目的探讨肿瘤转移抑制基因KAI1、基质金属蛋白酶9（MMP-9）在子宫内膜异位症（Endometriosis，EMS；内异症）组织中的表达及意义。方法对本院53例内异症者（研究组）及30例正常子宫内膜者（对照组），应用免疫组化sP法检测不同子宫内膜组织中KAI1及MMP-9的表达，分析两组KAI1及MMP-9表达水平及相关性。结果KAI1在研究组中呈低表达，而MMP-9呈高表达；KAI1对照组中呈高表达，而MMP-9呈低表达，两组KAI1及MMP-9表达水平比较差异均统计学有意义（P〈0．05）。内异症和正常子宫内膜组织中KAI1与MMP-9水平均呈负相关（r=-0．402，-0．550，P〈0．05）。结论KAI1及MMP-9在内异症组织中表达呈负相关，其可能参与了EMS异位内膜的转移和侵袭中作用，促进内异症的发生和发展。可成为EMS预后和复发的监测指标之一。Objective To discuss the expression of tumor shift suppressor gene KAI1, matrix metal proteinase 9 （MMP-9） in endometriosis sickness in dystopia internal membrane and its significance. Methods In 53 patients and 30 healthy controls, the expression of KAI1, MMP-9 in the endometriosis was detected with immunohistochemistry SP method, and the relationship was analyzed. Results KAI1 had low expression in EMS patients, while MMP-9 was highly expressed. In the control group, KAI1 was highly expressed while MMP-9 lowly expressed, and the differences between two groups were remarkably significant （ P 〈 0. 05）. KAI1 and the MMP-9 expression showed negative correlation between two groups. Conclusions KAI1 and MMP-9 was negatively expressedin EMS, which may play a role in the EMS prognosis. KAI1 and MMP-9 may be served as the prognosis and monitor markers for EMS.

关 键 词：原癌基因蛋白质类/代谢 基质金属蛋白酶9/代谢 基因 肿瘤抑制 子宫内膜异 位症/代谢 

分 类 号：R711.71[医药卫生—妇产科学]