双柏喷雾剂与双柏喷膜剂制备工艺比较  

Comparative Preparation Process of Shuangbai Spray and Shuangbai Film Spraying Agent

作　　者：朱小凤[1] 魏刚[1] 何坦[1] 林华燕[1] 刘柳芳[1] 张琼丹[1] 

机构地区：[1]广州中医药大学,广州510006

出　　处：《中国实验方剂学杂志》2011年第24期4-6,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技部"十一五"科技支撑计划项目(2008BAI53B074);广东高校科技成果转化重大项目(cgzhzd1009)

摘　　要：目的:比较双柏喷雾剂与双柏喷膜剂制备工艺的优劣。方法:采用水提醇沉法制备双柏喷雾剂,全方醇提法制备双柏喷膜剂,比较两者的药材用量、指标成分含量及其转移率、成膜性能。结果:双柏喷雾剂的药材用量为1 001 g,大黄素含量82.70 mg,转移率8.63%,盐酸小檗碱含量97.61 mg,转移率6.63%,喷在皮肤上不能成膜;双柏喷膜剂药材用量140 g,大黄素含量99.67 mg,转移率74.38%,盐酸小檗碱含量113.79 mg,转移率55.24%,喷在皮肤上5 min内即可成膜,成膜性能好。结论:双柏喷膜剂的制备工艺简单,药材利用率高,成膜性能好,优于双柏喷雾剂的制备工艺。Objective： To contrast preparation technology of the Shuangbai spray and Shuangbai film spraying agent.Method： Adopted water extraction and alcohol sink method to produce Shuangbai spray and adopted ethanol extraction method to produce Shuangbai film spraying agent,compared dosage of medicinal materials,the content of index components and transfer rate,film performance.Result： In Shuangbai spray,dosage of medicinal materials was 1 001 g and the content of the Emodin was 82.70 mg with it′s transfer rate was 8.63%,and the content of hydrochloride berberine was 97.61 mg with it′s transfer rate was 6.63%.It couldn′t become film when Shuangbai spray was sprayed onto skin.But in Shuangbai film spraying agent,dosage medicinal materials was 140 g and the content of emodin was 99.67 mg with it′s transfer rate was 74.38%,and the content of hydrochloride berberine was 113.79 mg with it′s transfer rate was 55.24%.It could become film with a good performance in five minutes when Shuangbai film spraying agent was sprayed onto the skin.Conclusion： Preparation technology of Shuangbai film spraying agent was simple,improved utilization rate of medicinal materials,had good film performance,and better than preparation technology of Shuangbai spray.

关 键 词：双柏喷雾剂 双柏喷膜剂 制备工艺 转移率 成膜 

分 类 号：R283.6[医药卫生—中药学]