蒡芎疏风颗粒对实验性偏头痛的影响  

Influence of Bangxiong Shufeng Granlues on Experimental Migraine

作　　者：马壮壮[1] 梁茂新[1] 张宏[1] 

机构地区：[1]辽宁中医药大学,沈阳110847

出　　处：《中国实验方剂学杂志》2011年第24期180-184,共5页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察蒡芎疏风颗粒(Bxsfkl)对实验性偏头痛的影响。方法:将小鼠分为空白、模型、实验药物3个剂量和中、西药对照组,以Bxsfkl低、中、高(9.75,19.5,39 g.kg-1.d-1)ig给药干预5 d,检测各组小鼠的物理和化学痛阈值。利用硝酸甘油制造偏头痛模型,观察治疗后各组大鼠行为变化和血浆5-羟色胺(5-HT)测值,考察Bxsfkl对实验性偏头痛的效应。结果:在小鼠甩尾实验中,Bxsfkl高剂量组提高小鼠痛阈值,在30,60,90,120 min分别与空白组比较,有统计学意义(P<0.05或P<0.01)。在小鼠醋酸扭体实验中,Bxsfkl中、高剂量组减少小鼠扭体次数,与空白组比较有统计学意义。在硝酸甘油所致偏头痛模型实验中,Bxsfkl低、中、高剂量组大鼠耳红消失时间与模型组比较均有显著差异;大鼠挠头次数在30～180 min与模型组比较,均能缓解挠头次数,高剂量组有统计学意义;大鼠爬笼次数在30～180 min与模型组比较,其中高剂量组有统计学意义。大鼠血浆5-HT含量模型组为(43.99±5.49)ng.g-1较正常对照组(82.62±11.18)ng.g-1显著降低(P<0.01);与模型组比较,各治疗组血浆5-HT含量增加,且均有统计学意义。结论:Bxsfkl能明显提高小鼠的痛阈,显著缓解模型大鼠因头痛所致耳红、挠头、爬笼等现象,具有增加血浆中5-HT含量的作用。Objective： To observe the influence of Bangxiong Shufeng granlues on the experimental migraine.Method： The mice was divided into blank control group,model group,three doses groups of Bangxiong Shufeng granlues（9.75,19.5,39 g·kg-1·d-1）,Chinese medicine and western medicine control groups.The chemical and physical pain threshold were observed nitroglycerin was used to make rat migraine model,the change of behavior and plasma serotonin（5-HT） were detected.Result： In test of mice tail flick.Bangxiong Shufeng granlues with high dose increased the pain threshold at 30,60,90,120 min,respectively（P〈0.05 or P〈0.01）.In acetic acid induced writhing model,Bangxiong Shufeng granlues with medium and high dose decreased writhing frequency.In the test of migraine model by nitroglycerin.Bangxiong Shufeng granlues with low,medium and high dose decreased disappeared time of red eras and,high dise group decreased the frequency of scratching head and climbing cage frequency during the period of 30 to 80 min and 30 to 180 min compared with model group,the treatment group increased 5-HT content.Conclusion： Bangxiong Shufeng granlues would have effects on migraine model.

关 键 词：蒡芎疏风颗粒 偏头痛模型 痛阈 5-羟色胺 

分 类 号：R285.5[医药卫生—中药学]