天钩降压胶囊对肾血管性高血压大鼠血压的影响  

Influence of Tiangou Jiangya capsule on blood pressure in renovascular hypertension rats

作　　者：杨庆[1] 李玉洁[1] 刘晓霓[1] 翁小刚[1] 陈颖[1] 朱晓新[1] 韩晓[1] 邹丽娟[1] 李丹[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国中药杂志》2011年第23期3344-3348,共5页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09103-403)

摘　　要：目的:观察天钩降压胶囊对肾血管性高血压大鼠的血压的影响并初步探讨其作用机制。方法:将72只Wistar大鼠随机分为正常对照组、模型组、卡托普利组(0.03 g.kg-1)、天钩降压胶囊低、中、高剂量组(5.4,10.8,21.6 g.kg-1)。采用无创血压仪测量鼠尾动脉血压;采用放射免疫法测定大鼠血中PRA,AngⅡ,ALD,6-酮-前列腺F1α,ET和TXB2的含量;采用硝酸还原酶法测定大鼠血中NO的含量。结果:模型组收缩压、舒张压和平均压明显升高,大鼠血中PRA,AngⅡ,ALD明显降低,ET水平明显增高;天钩降压胶囊能明显降低模型大鼠的血压,提高大鼠血中肾素活性,降低大鼠血中ET含量,升高NO含量。结论:天钩降压胶囊具有降低肾性高血压模型大鼠血压的作用,其降低血压的机制可能与其调控模型大鼠RAAS系统的分泌以及改善血管内皮的功能有关。Objective： To observe the effect of Tiangou Jiangya capsule（TJC） on blood pressure in renovascular hypertension rats and explore its possible mechanism. Method： Seventy-two Wistar rats were randomly divided into normal control group, model group, captopril group, TJC small, medium and high dose groups. Non-invasive blood pressure measurement was used to detect the arterial blood pressure of rat tails. PRA, Ang Ⅱ, ALD, 6-Keto-PGF1α, ET and TXB2 content in blood was measured by radioimmunoassay. NO content in blood was determined by method of nitrate reductase. Result： The systolic, diastolic and mean pressure significantly increased, serum PRA, Ang Ⅱ, ALD decreased, ET levels significantly increased in model group rats. TJC significantly reduced blood pressure, improved the plasma renin activity, decreased ET levels and increased NO content of model rats. Conclusion： TJC can reduce blood pressure of renovascular hypertention rats, and the mechanism may be related to its regulating lower blood pressure regulation of the secretion of RAAS system and improving vascular endothelial function.

关 键 词：肾血管性高血压 肾素-血管紧张素-醛固酮系统 血管内皮功能 天钩降压胶囊 

分 类 号：R285[医药卫生—中药学]