中国汉族人群基质金属蛋白酶9基因-1562C>T多态性与冠心病易感性的Meta分析  

Association of-1562C>T Polymorphism of Matrix Metalloprotein-9 Gene and Coronary Artery Disease in Chinese Han Population: a Meta-analysis

作　　者：张步春[1] 周志文[1] 徐亚伟[1] 

机构地区：[1]同济大学附属第十人民医院心内科,上海市200072

出　　处：《中国动脉硬化杂志》2011年第12期1037-1042,共6页Chinese Journal of Arteriosclerosis

摘　　要：目的综合评价中国汉族人群基质金属蛋白酶9基因-1562C>T多态性与冠心病易感性相关。方法通过文献检索收集2010年12月以前完成或发表的中国汉族人群基质金属蛋白酶9基因-1562C>T多态性与冠心病相关性的病例对照研究,剔除不符合要求的文献,以漏斗图检验入选文献的偏倚,并根据各入选文献结果的同质性检验结果进行数据合并,计算总OR值,Meta分析采用Revman5.0及StatalO.0统计软件。结果共7篇文献符合条件纳入研究,入选文献无明显偏倚,Meta分析显示TT+CT基因型比CC基因型OR=1.47(95%CI为1.20～1.78,P=0.0001);T等位基因比C等位基因OR=1.41(95%CI为1.17～1.69,P=0.0002);CC基因型比CT+TT基因型OR=0.68(95%CI为0.55～0.82,P<0.0001);CT基因型比CC+TT基因型OR=1.45(95%CI为1.19～1.77,P=0.0002)。结论基质金属蛋白酶9基因-1562C>T多态性与中国汉族人群冠心病易感性相关,T等位基因可能是冠心病遗传危险因素。Aim Association between the-1562CT single nueleotide polymorphisms of matrix metalloprotein-9 gene and the occurrence coronary artery disease in Chinese Han population was studied. Methods Case-control studies published before 31 Dec.2010 about the association of matrix metalloprotein-9 gene-1562CT polymorphism and coronary artery disease in Chinese Han population were searched,all the literatures were evaluated and abstracted based on the defined selection criteria by two independent investigators.Publication bias was tested by funnel plot and the odd ratios of all studies were combined dependent on the result of heterogeneity test among the individual studies.The software Review Manager（version 5.0） and Stata（version 10.0） were used for meta-analysis. Results Seven studies were analyzed,there was no publication bias in 7 reviewed studies.The summarized odds ratios of TT and CT genotype combination versus CC genotype across all 7 studies was OR= 1.47（95% CI was 1.20~1.78,P=0.0001）;T genotype versus C genotype was OR=1.41（95% CI was 1.17~1.69,P=0.0002）;CC genotype versus TT and CT genotype combination was OR= 0.68（95% CI was 0.55~0.82,P0.0001）;CT genotype versus CC and TT genotype combination was OR=1.45（95% CI was 1.19~1.77,P=0.0002）. Conclusions In Chinese Han population,-1562CT polymorphism in matrix metalloprotein-9 gene is associated with susceptibility of coronary artery disease and T allele might be a risk factor for coronary artery disease.

关 键 词：冠心病 基质金属蛋白酶9 基因多态性 中国汉族人群 META分析 

分 类 号：R18[医药卫生—流行病学]