诊断性基因表达谱模式可信区间图示法  

The study on patterns of diagnostic gene expression profiles by graphical methods of confidence interval

作　　者：刘岭[1] 程迪祥[2] 陈洪 陈品一[1] 易东[1] 

机构地区：[1]第三军医大学卫生统计学,重庆400038 [2]重庆邮电大学,重庆400065 [3]重庆市光学机械研究所,重庆401123

出　　处：《激光杂志》2011年第6期95-95,共1页Laser Journal

基　　金：国家自然科学基金资助项目(编号:30872184)

摘　　要：目的:探讨诊断性基因表达谱模式提取方法,为疾病的诊断打下基础。方法:基于正常人、骨髓增生异常综合征和原发性急性髓系白血病3种情况的基因表达谱数据,利用可信区间方法描述表达变化趋势,从而建立表达谱的模式;同时利用差异性比较的可信区间方法,得到差异表达基因的图示法。结果:得到了基因表达谱模式;建立了多组差异表达基因的示意图,结论:建立的基因表达模式图。为疾病的芯片诊断打下了基础;采用的差异基因表达图示方法,直观形象地展示了差异表达基因;特别是针对多个组的比较具有重要意义。Objective： To find the extraction method on the patterns of diagnostic gene expression,so to lay the foundation for the diagnosis of disease.Methods： Three kinds of gene expression data are used in this research they are normal,primary myelodysplastic syndrome and acute myeloid leukemia.Trends in expression profiles are described by confidence interval approach.The gene expression patterns are established.While graphical method on multiple different genes is obtained by taking advantage of the hypothesis test of confidence interval.Results： Patterns on trend of gene expression has been extracted.Screening method on different genes is got by confidence interval diagram.Conclusions： The graphical methods of confidence interval are very useful.

关 键 词：基因表达 表达谱模式 可信区间 

分 类 号：TN248.1[电子电信—物理电子学]