MiRNAs对细胞色素P450s药物代谢酶系调控作用的研究进展  

Development of microRNA-dependent control of cytochrome P450

作　　者：温纯洁[1] 傅利娟[1] 吴兰得[1] 陈旺[1] 张涛[1] 周宏灏[1] 

机构地区：[1]重庆医科大学生命科学研究院,重庆400016

出　　处：《中国临床药理学与治疗学》2011年第11期1304-1309,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：重庆市教委科学技术研究项目(KJ090306);国家自然科学基金(84402511);重庆市自然科学基金(cstc2011jjA1004);中国博士后基金(2011MS00669)

摘　　要：MicroRNAs(MiRNAs)是一类内源性非编码小分子RNA,一般含有19～25个寡核苷酸,通过与靶mRNA 3'端非翻译区(3'UTR)完全或不完全互补配对,引起mRNA降解或翻译抑制,发挥基因调控作用。MiRNAs在多种生物学过程中都有重要作用,其异常调节会导致各种疾病发生,所以miRNAs被认为可能是新的治疗靶点。MiRNAs在遗传药理学中的作用最近才被研究。化学物质、药物、激素或者是病理状态引起的miRNAs表达的改变可能会导致药物代谢和药物效应的改变。本文主要从miRNAs对细胞色素P450代谢酶和核受体的转录后调控作用作一综述。MicroRNAs（miRNAs） are a class of short,non-coding RNAs of 19-25 nucleotides that negatively regulate gene expression by inducing translational inhibition or cleavage of their target mRNAs through binding to the 3′-untranslated regions of target messenger RNAs（mRNAs）.Since miRNAs regulate every aspect of cellular function,their dysregulation is associated with a variety of diseases.Therefore,miRNAs are now considered new therapeutic targets.However,the roles of miRNAs in pharmacogenetics have only recently been revealed.The miRNA expression is readily altered by chemicals,drugs,hormones or diseases,and the dysregulation of specifc miRNAs might lead to changes in the drug pharmacokinetics or pharmacodynamics changes.This review describes the current knowledge on the post-transcriptional regulation of cytochrome P450s and nuclear receptors by miRNAs.

关 键 词：MICRORNA 细胞色素P450 遗传药理学 转录后调控 

分 类 号：R968[医药卫生—药理学]