肝硬化患者HBV血清标志物、HBV-DNA与前S1抗原的关系分析  

Relationships among HBV serum markers,HBV-DNA and pre-S1 antigen in patients with hepatocirrhosis

作　　者：唐宇[1] 

机构地区：[1]第三军医大学西南医院感染科实验室,重庆400038

出　　处：《西南国防医药》2011年第12期1284-1286,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的了解肝硬化患者血清中乙肝病毒(HBV)的感染状况,探讨HBV血清标志物(HBV-M)、HBV-DNA与前S1抗原三者之间的内在关系,为临床抗病毒治疗肝硬化提供依据。方法对451例肝硬化患者血清进行HBV-M、HBV-DNA、前S1抗原测定并分析。结果 451例肝硬化患者中,HBV感染率85.4%(385/451),HBsAg阳性率71.4%(322/451);在HBsAg阳性者,感染模式以HBeAg阴性多见,占75.5%(243/322);HBV-DNA和前S1抗原的阳性率分别为82.3%(265/322)、63.4%(204/322);在HBsAg、HBeAg和抗-HBc 3项阳性模式中,HBV-DNA、前S1抗原阳性率最高,分别为98.7%,78.4%。HBV-DNA的阳性率高于前S1抗原(χ2=29.20,P<0.05)。结论肝硬化的发生与HBV的感染密切相关,以HBeAg阴性多见;检测肝硬化患者血清中HBV-DNA、前S1抗原可反映患者体内HBV的复制与活动性程度,弥补HBV-M在肝硬化检测中的不足。Objective To understand the situation of hepatitis B infection in patients with hepatocirrhosis,and to explore the relationships among hepatitis B virus markers（HBVM）,HBV-DNA and pre-S1 antigen（pre-S1-Ag）in order to provide evidence for clinical antiviral therapy of hepatocirrhosis.Methods Serum HBVM,HBV-DNA and pre-S1-Ag in 451 patients with hepatocirrhosis were detected and analyzed.Results Among these patients,the infection rate of HBV was 85.4%（385/451）and the positive rate of the HBsAg was 71.4%（322/451）.Among the patients with positive HBsAg,the infection patterns containing negative HBeAg were the most,which accounted for 75.5%（243/322）.The positive rates of HBV-DNA and pre-S1-Ag were 82.3%（265/322）and 63.4%（204/322）,respectively.Among the patterns of HBsAg（＋）,HBeAg（＋）and anti-HBc（＋）,the positive rate of HBV-DNA and pre-S1-Ag were much higher,and were 98.7% and 78.4%,respectively.The positive rate of HBV-DNA was higher than that of pre-S1-Ag（χ2=29.20,P0.05）.Conclusion The hepatocirrhosis is closely related to HBV infection in which negative HBeAg is predominant.Detection of HBV-DNA and pre-S1-Ag in blood serum of patients with hepatocirrhosis can reflect the degree of HBV replication and activeness in those patients,which makes up for the deficiency of HBVM in the hepatocirrhosis detection.

关 键 词：肝硬化 HBV血清标志物 HBV-DNA 前S1抗原 

分 类 号：R657.31[医药卫生—外科学]