移居汉族与平原汉族胎盘组织基因表达谱的差异  

Differences of placenta gene expression between immigrated Han women and Han ones in plain

作　　者：刘福玉[1,2] 罗勇军[3,2] 高文祥[1,2] 赵秀欣[1,2] 宋桐林[1,2] 索朗[4] 高钰琪[1,2] 

机构地区：[1]第三军医大学高原军事医学系病理生理学与高原生理学教研室,重庆400038 [2]高原医学教育部重点实验室 [3]第三军医大学高原军事医学系高原疾病学教研室 [4]西藏自治区第一人民医院妇产科

出　　处：《西南国防医药》2011年第12期1347-1349,共3页Medical Journal of National Defending Forces in Southwest China

基　　金：国家自然科学基金面上项目(30900715);国家科技支撑计划项目(2009BAI85B01);973项目(2012CB518200)

摘　　要：目的研究移居汉族与平原汉族的胎盘组织的基因表达谱变化。方法采用基因芯片,筛选出移居汉族与平原汉族的胎盘差异表达基因。结果表达差异以≥1.5或≤0.67为标准时,移居汉族与平原汉族相比,Itga5基因(integrinalpha 5)的表达下调。结论移居汉族与平原汉族相比,胎盘组织的Itga5基因的表达降低,可能是高原产后出血发生率较高的重要原因。Objective To explore the changes of the placenta gene expression of the immigrated Han women and the Han ones in plain areas.Methods The placentas of the immigrated Han women and the Han ones in the plain areas were screened by the gene chip.Results When the standard of expression difference was ≥1.5 or ≤0.67,the integrin alpha 5（Itga 5）gene expression of the immigrated Han women was down-regulated,compared with that of the Han ones in the plain areas.Conclusion Compared with the Han women in the plain areas,the Itga 5 gene expression of the immigrated Han ones decreased,which may be the most important cause for the high incidence of postpartum hemorrhage at high altitude.

关 键 词：高原 移居汉族 平原汉族 胎盘 基因表达谱 

分 类 号：R714.56[医药卫生—妇产科学]