鼠源性神经生长因子联合高压氧治疗颅脑外伤后偏瘫患者的疗效分析  

The effect of mouse-genic nerve growth factor and hyperbaric oxygen therapy on hemiplegia after traumatic brain injury

作　　者：沈李奎[1] 陆明[1,2] 蒋栋毅[1] 赵广华[2] 王之敏[1] 

机构地区：[1]上海交通大学医学院苏州九龙医院神经外科,江苏苏州215021 [2]苏州九龙医院神经康复中心

出　　处：《中国康复医学杂志》2011年第12期1117-1120,共4页Chinese Journal of Rehabilitation Medicine

摘　　要：目的:探讨鼠源性神经生长因子联合高压氧对颅脑外伤后偏瘫患者的治疗效果。方法:随机选取40例符合标准的颅脑外伤后偏瘫患者作为治疗组,同时随机抽取符合标准的41例患者作为对照组。治疗组在常规治疗的基础上,给予鼠源性神经生长因子(mNGF)18μg/d,共用28d。所有患者在病情允许的情况下尽早行高压氧(HBO)治疗。分别记录两组患者治疗前、治疗3个月后的神经功能缺陷评分(NFDS)、运动功能评分(FMA)。结果:治疗后两组患者NFDS均有下降,FMA均有改善,各组治疗前后差异有显著性(P<0.01),其中治疗组改善明显优于对照组(P<0.05)。结论:早期应用mNGF联合HBO治疗颅脑外伤后偏瘫患者能更显著改善患者功能预后。Objective：To investigate the effect of mouse-genic nerve growth factor（mNGF） and hyperbaric oxygen（HBO） on patients with hemiplegia after traumatic brain injury.Method：Forty brain injuried patients were selected randomly as treatment group,as well as the other forty-one brain injuried patients with hemiplegia were selected as control group.In treatment group patients were treated with mNGF 18μg/d（sharing 28d） based on routine clinical therapy,HBO treatment were administered as soon as possible.In control group,patients received HBO treatment and routine clinical therapy only.Assessment of neurological function defect scale（NFDS）and Fugl-Meyer assessment scale（FMA）were performed and recorded before treatment and three months later respectively.Result：NFDS and FMA scores improved after treatment（P0.01） in both 2 groups,and the scores in treatment group were better than those in control group significantly（P0.05）.Conclusion：Early application of mNGF associated with HBO treatment can improve the prognosis in patients with hemiplegia after traumatic brain injuries.

关 键 词：鼠源性神经生长因子 高压氧 颅脑外伤 偏瘫 

分 类 号：R651.15[医药卫生—外科学] R459.6[医药卫生—临床医学]