踏车运动对老年稳定型心绞痛患者的影响  

The effect of treadmill exercise on the prognosis of elderly patients with stable angina pectoris

作　　者：宋红[1] 邓景贵[1] 陶希[1] 陈美娟[1,2] 

机构地区：[1]湖南省马王堆医院康复医学科,长沙410016 [2]湖南省马王堆医院心内科

出　　处：《中国康复医学杂志》2011年第12期1140-1143,1148,共5页Chinese Journal of Rehabilitation Medicine

摘　　要：目的:探讨踏车运动对老年稳定型心绞痛患者的影响。方法:141例老年稳定型心绞痛患者随机分成治疗组(68例)和对照组(73例),治疗组进行踏车运动和常规药物治疗,对照组实行常规药物治疗,疗程4个月。使用放射免疫法检测实验前后血浆TXA2及免疫比浊法检测CRP、LDL-C和HDL-C水平,监测实验过程中心率及血压变化,比较实验前后两者有无差异,并调查对比两组实验结束后1月内心绞痛的发生率。结果:治疗组有2例患者因不能耐受退出研究。对照组治疗后血浆CRP、TXA2和LDL-C水平分别下降58.30%、45.64%和36.04%,HDL-C升高0.71%;治疗组治疗后血浆CRP、TXA2和LDL-C水平分别下降65.47%、38.29%和36.18%,HDL-C升高2.11%;治疗组较对照组CRP下降明显,差异有显著性意义(P<0.05);但两组间TXA2、LDL-C下降及HDL-C升高无明显差异(P>0.05)。治疗前后两组间血压、心率变化无明显差异。两组治疗后均进行随访1个月,治疗组(5/66)较对照组(16/73)心绞痛发生率明显减少,差异有显著性意义(P<0.05)。结论:踏车运动能明显降低老年稳定型心绞痛患者心绞痛发生率,其机制可能与降低CRP表达有关。Objective： To study the effect of treadmill exercise on the prognosis of elderly patients with stable angina pectoris （SAP） patients. Method： One hundred and forty-one SAP patients were divided randomly into treadmill exercise group （68 cases） and control group （73 cases）. The patients in treadmill exercise group received treadmill and conventional drug treatment for 4 months, and those in control group received routine drug treatment only. The differences on levels of plasma CRP, TXA2, LDL-C and HDL-C were defected between before and after experiment; the diversities of heart rate and blood pressure were monitored in experiment process and the differences between before and after experiment were compared; and the incidences of angina pectoris of two groups in 1 month after experiment were investigated. Result： Two patients in treadmill exercise group signed off the research because of intolerance. The levels of plasma CRP, TXA2 and LDL-C in control group after treatment decreased by 58.30%, 45.64% and 36.04% respectively, but HDL-C elevated 0.71%; the levels of plasma CRP, TXA2 and LDL-C in treadmill exercise group after treatment decreased by 65.47%, 38.29% and 36.18% respectively, but HDL-C elevated 2.11%; the level of plasma CRP in treadmill exercise group decreased more significantly （P0.05） than that in control group, but the decrease of TXA2 and LDL-C and rise of HDL-C had less significant differencely in two groups （P0.05）. The heart rate and blood pressure had less significant difference between two groups before and after treatment. The incidence of angina pectoris in treadmill exercise group （5/66） was less （P0.05） than that in control group （16/73） when the two groups were followed up after treatment in 1 month. Conclusion： Treadmill exercise could significantly reduce the incidence of angina pectoris of elderly SAP patients, its mechanism maybe concerned with the decreasing of expression of plasma CRP.

关 键 词：踏车运动 稳定型心绞痛 老年 C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病] R493[医药卫生—内科学]