参百润肺胶囊急性毒性实验研究  

Experimental Study of the Acute Toxicity of Shenbai Runfei Capsule

作　　者：高淑丽[1] 黄艳[2] 吴宗耀[2] 

机构地区：[1]石家庄市第四医院,河北石家庄050000 [2]石家庄市第五医院,河北石家庄050021

出　　处：《中医学报》2011年第12期1474-1474,共1页Acta Chinese Medicine

基　　金：河北省卫生厅计划项目(编号:05215);河北省科技支撑计划项目(编号:07276475);河北省科技攻关项目(编号:042761452);河北省医学科学研究重点课题(编号:20110093)

摘　　要：目的:探讨参百润肺胶囊对小鼠的急性毒性反应。方法:实验前禁食不禁水12 h,参百润肺胶囊组按小鼠可灌服的最大体积(0.04 mL/g)灌服最大可灌服浓度的参百润肺胶囊混悬液(0.5 g/mL);生理盐水组小鼠灌服最大体积(0.04 mL/g)的生理盐水。灌胃,3次/d,每次间隔8 h,然后给动物以正常饮食,连续观察14 d。结果:小鼠未出现死亡。结论:小鼠每日积累最大耐受量为60 g原生药/kg,该量已为临床用量的460倍以上,可以认为临床用药安全。Objective：To study the acute toxicity reaction of mice when they are given Shenbai runfei capsules.Methods：All mice only took water without food for 12 h before experiment.The group of mice which were given Shenbai Runfei Capsule were irrigated mixed Shenbai Runfei suspension with the maximum PH indicator（0.5 g/mL）according to mice’s maximum volume of stomach-pouring（0.04 mL/g）;the group of mice which were given NS were irrigated the maximum volume NS（0.04 mL/g）,three times a day,8h for every interval;then all mice were given normal food intake,and continuously observed for 14 d.Results：No death was found in the mice.Conclusion：The maximum accumulated tolerable dosage of mice is 60 g/kg of the crude drugs per day,which is more than 460 times of the clinical dosage.The drug is considered safe in clinical application.

关 键 词：参百润肺胶囊 急性毒性 最大灌胃体积 最大耐受量 小鼠 

分 类 号：R285.5[医药卫生—中药学]