成熟卵泡获卵率对体外受精结局的影响  

The influence of retrieved oocyte rate of mature follicles on the outcomes during in vitro fertilization & embryo transfer procedure

作　　者：马黔红[1] 黄仲英[1] 樊伟[1] 

机构地区：[1]四川大学华西第二医院妇产科,成都610041

出　　处：《中国妇产科临床杂志》2011年第6期414-417,共4页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的比较在体外受精-胚胎移植/卵细胞浆内单精子注射(IVF-ET/ICSI)过程中,控制性超促排卵(COH)后成熟卵泡获卵率对IVF-ET/ICSI的实验室和临床结局的影响。方法回顾性分析2010年5月至2010年12月四川大学华西第二医院行IVF-ET/ICSI治疗的693例患者,共746个周期,根据获卵率将患者分为A组:获卵率≥80%;B组:获卵率50%～79%;C组:获卵率30%～49%;D组:获卵率<30%。比较4组患者的临床和实验室结局。结果 A、B组卵子成熟率、受精率、卵裂率和可移植胚胎形成率等各项临床和实验室结局比较,差异均无统计学意义(P>0.05)。随着获卵数的减少,获卵数最低的D组的卵子成熟率、受精率、卵裂率和可移植胚胎形成率与A组和B组比较,差异有统计学意义(P<0.05);同时,D组的临床妊娠率、胚胎种植率和累积妊娠率明显低于其他各组(P<0.05)。C组受精率、卵裂率、可移植胚胎形成率和临床妊娠率也显著低于A组(P<0.05),C组卵裂率、临床妊娠率低于B组(P<0.05),但C组的累积妊娠率与A组和B组相似(P>0.05)。结论获卵率减少可导致卵子成熟率、受精率、卵裂率和可移植胚胎形成率下降,直接导致临床妊娠率下降。Objective To investigate the influence of retrieved oocyte rate on clinical and laboratory results during in vitro fertilization and embryo transfer or intracytoplasmic sperm injection procedure.Methods 746 IVF/ICSI cycles（693 patients）were analysed retrospectively in West China Second University Hospital of Sichuan University from May to December in 2010.Based on retrieved oocyte rate,all these cycles were divided into four groups：group A,retrieved oocyte rate ≥80%;group B,retrieved oocyte rate 50%～79%;group C,retrieved oocyte rate 30%～49%;group D,retrieved oocyte rate 30%.Results There were no statistic difference between group A in maturation rate of oocytes,fertilization rate,cleavage rate and embryo formation rate that could be transferred（P0.05）.The cases from group D obtained the lowest number of retrieved oocytes in the four groups,and there were significantly lower in group D than in group A and B in maturation rate of oocytes,fertilization rate,cleavage rate and embryo formation rate that could be transferred（P 0.05）,which resulting to the lower clinical pregnancy rate,implantation rate and cumulative pregnancy rate in group D than in group A and B（P0.05）.Also,there were significantly lower in fertilization rate,cleavage rate,embryo formation rate that could be transferred in group C than in group A（P0.05）,but cumulative pregnancy rate in group C was similar to group A and B.Conclusions Decreased retrieved oocyte rate may cause decreased oocyte maturation rate,fertilization rate,cleavage rate and good quality embryo rate,so as to lessen the clinical pregnancy rate.

关 键 词：体外受精-胚胎移植 控制性超促排卵 空卵泡综合征 

分 类 号：R714.8[医药卫生—妇产科学]