多元氨基酸共聚物/磷酸钙复合材料椎间融合器的设计制备及压缩强度测试  

The Design,Preparation and Compressive Strength Testing of Interbody Fusion Cages Made from a Composite of Multi-amino Acid Copolymer/Tri-calcium Phosphate

作　　者：周春光[1] 宋跃明[1] 屠重棋[1] 裴福兴[1] 段宏[1] 刘立岷[1] 李鸿[2] 

机构地区：[1]四川大学华西医院骨科,成都610041 [2]四川大学物理学院,成都610064

出　　处：《生物医学工程学杂志》2011年第6期1136-1140,共5页Journal of Biomedical Engineering

基　　金：国家科技支撑计划项目资助(2007BAE13B04)

摘　　要：设计制备多元氨基酸共聚物/磷酸钙复合材料椎间融合器(MAACP/TCP Cage)并测试其压缩强度。对16个成年雌性山羊颈椎C3-4节段标本进行X片正侧位检查,排除颈椎病变,测量:C3-4椎间高度(DSH)、C3下终板矢状径(SDLE3)、C4上终板矢状径(SDUE4)、C3下终板横径(CDLE3)、C4上终板横径(CDUE4),根据测得的解剖参数设计MAACP/TCP Cage及形状尺寸相同的钛合金Cage,MAACP/TCP Cage采用注塑成块精加工而成,钛合金Cage经机械加工制作。压缩强度测试分三组进行:三面皮质髂骨组(取自山羊)、MAACP/TCP Cage组和钛合金Cage组,每组样本数为8个,均制备成相同尺寸:12mm×10mm×6mm,在万能试验机上测试各样品的压缩强度分别为:DSH(4.78±0.17)mm、SDLE(15.06±0.53)mm、SDUE4(12.46±0.44)mm、CDLE3(14.47±0.51)mm、CDUE4(12.15±0.65)mm。成功设计制备MAACP/TCP Cage,其压缩强度达到76.34MPa,明显高于三面皮质髂骨块组的压缩强度(18.41MPa),测试机器的最大加载力为50 000N,未能准确测出钛合金Cage组的压缩强度,其值应大于541.35MPa。实验证明,MAACP/TCP Cage组的压缩强度明显高于山羊三面皮质髂骨块组的压缩强度。This research was to design and prepare interbody fusion cages using composite materials of multi-amino acid copolymer/tri-calcium phosphate （MAACP/TCP） and to test compressive strength of the cages. 16 specimens of C3-4 segments from female adult goats were scanned by X-ray to exclude disease of cervical spine, and then ana- tomical data were measured, i.e. disc space height of C3-4 segment （DSH）, sagittal diameter of C3 lower endplate （SDLE3）, sagittal diameter of C4 upper endplate （SDUE4）, coronary diameter of C3 lower endplate （CDLE3）, and coronary diameter of C4 upper endplate （CDUE4）. According to the anatomical data, we designed and prepared the interbody fusion cage using the composite of MAACP/TCP and titanium with the same sizes. The MAACP/TCP Cages were made with the method of injection molding and finish machining, and titanium Cages were made with machining. In the testing of compressive strength of Cages, the specimens were divided into three groups： tricortical iliac crest bone group （isolated from goats）, MAACP/TCP Cage group and titanium Cage group. There were 8 specimens in every group with the same sizes, the length of 12mm, the width of 10mm, and the height of 6mm. The compressive strength of all specimens was tested on a universal testing machine. The values of DSH, SDLE3, SDUE4,CDLE3 andCDUE4 were （4.78±0.17）mm, （15.06±0.53）mm, （12.46±0.44）mm, （14.47±0.51）mm and （12. 15± 0. 65）mm, respectively. MAACP/TCP Cage was successfully designed and made with a compressive strength of 76.34MPa, which was much higher than that of tricortical iliac crest bone （18.41MPa）. The maximal loading of universal testing machine was 50 000N, so the compressive strength of titanium Cages, whose value should be more than 541.3SMPa, could not be tested precisely. It is feasible to make cages with MAACP/TCP composite, and the compressive strength of MAACP/TCP Cages was much higher than that of tricortical iliac crest bone isolated from goats.

关 键 词：可降解材料 复合材料 椎间融合器 压缩强度 

分 类 号：R681.55[医药卫生—骨科学]