呼吸性窦性心律不齐定量分析研究进展  

Research Progress of Quantitative Analysis for Respiratory Sinus Arrhythmia

作　　者：孙聪聪[1] 张政波[2] 王步青[2] 刘洪运[2] 昂清[1,2] 王卫东[1,2] 

机构地区：[1]北京理工大学信息与电子学院,北京100081 [2]解放军总医院医学工程保障中心,北京100853

出　　处：《生物医学工程学杂志》2011年第6期1227-1231,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金青年基金资助项目(60801009);国家自然科学基金面上项目资助(60971044);北京市自然科学基金面上项目资助(3102028)

摘　　要：呼吸性窦性心律不齐(RSA)是一种心率随呼吸周期性波动的生理现象。近年来在临床上常被用作心迷走神经张力的非侵入式检测指征。但它的定量分析受呼吸参数、体位、体动等因素影响,使得至今还没有建立起一个通用的定量分析标准和校准方法。本文主要介绍了五种常见的定量分析方法:相邻R-R间期差值均方根(RMSSD)法、峰谷(pvRSA)法、逐次呼吸余弦拟合(cosinor fitting)法、谱分析(spectral analysis)法以及时频联合分析(JTFA)法;同时本文介绍了定量分析中常见的呼吸参数校准方法:引导呼吸法、协方差分析统计学控制法、相对呼吸参数残余量法以及潮气量修正法。最后,对如何解决现阶段RSA定量估计中存在的问题做了展望。Respiratory sinus arrhythmia （RSA） is known as fluctuations of heart rate associated with breathing. It has been increasingly used as a noninvasive index of cardiac vagal tone in psychophysiological research recently. Its analysis is often influenced or distorted by respiratory parameters, posture and action, etc. This paper reviews five methods of quantification, including the root mean square of successive differences （RMSSD）, peak valley RSA （pvRSA）, cosinor fitting, spectral analysis, and joint timing-frequency analysis （JTFA）. Paced breathing, analysis of covariance, residua method and msRSA per liter tidal volume are adjustment strategies of measurement and analysis of RSA in this article as well. At last, some prospects of solutions of the problems of RSA research are given.

关 键 词：呼吸性窦性心律不齐 心迷走神经张力 呼吸率 潮气量 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]