生物蛋白胶复合骨髓间充质干细胞修复兔多层软组织缺损  

Fibrin glue combined with bone marrow mesenchymal stem cells to repair multi-layer soft tissue defects in rabbits

作　　者：谢富荣 林春博 严冬雪[2] 杨渊 

机构地区：[1]广西骨伤医院,广西壮族自治区南宁市530012 [2]桂林医学院附属医院,广西壮族自治区桂林市541001

出　　处：《中国组织工程研究与临床康复》2011年第47期8773-8776,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：广西科技厅资助项目(桂科攻10124001B-55);广西科技厅资助项目(桂科攻0816004-15);广西科技厅资助项目(桂科自0728077);广西科技厅资助项目(桂科自0832157);广西科技厅资助项目(桂科攻0592007-1G)~~

摘　　要：背景:符合软组织生理结构的生物蛋白胶适合作为修复软组织缺损的载体材料。目的:观察生物蛋白胶复合骨髓间充质干细胞修复软组织缺损的可行性。方法:在新西兰大白兔大腿处造成深达肌肉层,直径大于3cm的软组织缺损。将24只新西兰大白兔随机分为3组,实验组将同种异体来源的骨髓间充质干细胞复合生物蛋白胶注射到软组织缺损处,对照组将生物蛋白胶注射到软组织缺损处,模型组造模后不注射。结果与结论:术后14,21d创面收缩率,实验组>对照组>模型组(P<0.01);愈合时间,实验组<对照组<模型组(P<0.01)。结果显示以生物蛋白胶为载体复合骨髓间充质干细胞能快速的修复多层软组织缺损。BACKGROUND： Fibrin glue meeting the physical structure of the soft tissue is appropriately used as a carrier material to repair soft tissue defects. OBJECTIVE： To investigate the feasibility of bone marrow mesenchymal stem cells combined with fibrin glue to repair soft tissue defects. METHODS： Soft tissue defects were made on the deep thigh muscle layer of New Zealand white rabbits with diameter greater than 3 cm. Twenty-four model rabbits were randomly divided into three groups： in experimental group, allogeneic bone marrow mesenchymal stem cells combined with fibrin glue were injected into the soft tissue defects; in control group, the fibrin glue was injected into soft tissue defects of rabbits; in model group, nothing was injected into soft tissue defects of rabbits. RESULTS AND CONCLUSION： Wound contraction rates at 14 and 21 days after operation were the experimental group control group the model group （P 0.01）; the healing time was the experimental group control group model group （P 0.01）. The results showed that the fibrin glue combined with bone marrow mesenchymal stem cells can rapidly repair multi-layer soft tissue defects.

关 键 词：生物蛋白胶 骨髓间充质干细胞 软组织缺损 创面愈合 生物材料 

分 类 号：R318[医药卫生—生物医学工程]