不同修饰剂对水热法制备羟基磷灰石粒径大小的影响  

Effect of organic modifiers on the size of hydroxyapatite prepared by hydrothermal method

作　　者：吴占敖[1] 宣志刚[1] 王春凤[1] 刘姒[1] 孙敏[1] 解放军第 

机构地区：[1]解放军第359医院,江苏省镇江市212001

出　　处：《中国组织工程研究与临床康复》2011年第47期8859-8862,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:不同粒径与形貌的纳米羟基磷灰石具有不同的表面特性与生物活性,通过对羟基磷灰石表面进行改性,进而合成出不同粒径的纳米羟基磷灰石,可扩大纳米羟基磷灰石的应用领域。目的:分析了水热合成法制备羟基磷灰石过程中,实验条件如修饰剂种类、pH值等对羟基磷灰石粒径的影响。方法:以磷酸与硝酸钙为原料,D-山梨醇、聚丙烯酸钠以及吐温80作为有机修饰剂,不同pH值条件下,水热合成不同粒径的羟基磷灰石。结果与结论:无修饰剂时,羟基磷灰石的粒径随pH增加迅速降低。聚丙烯酸钠的存在有利于小粒径羟基磷灰石的生成;D-山梨醇的存在有利于较大粒径羟基磷灰石的生成;吐温80的加入在一定程度上降低了羟基磷灰石粒径。BACKGROUND： Nanosized hydroxyapatite with different size and morphology has different surface performance and bioactivity. Different sized nanohydroxyapatite was synthesized via surface modification of hydroxyapatite; by this method, the application of nanosized hydroxyapatite can be extended. OBJECTIVE： To analyze the effect of experimental parameters, such as type of organic modifiers and pH value, etc. on the size of hydroxyapatite synthesized by hydrothermal method. METHODS： Hydroxyapatite with different sizes was synthesized starting from phosphoric acid and calcium nitrate and using D-sorbitol, sodium polyacrylate and Tween 80 as organic modifiers at different pH values. RESULTS AND CONCLUSION： In the absence of organic modifier, the size of hydroxyzpatite was decreased rapidly with the increase in pH values. The presence of sodium polyacrylate was beneficial to the formation of small-size hydroxapatite. The addition of D-sorbitol favored the formation of large-size hydroxyapatite. The presence of Tween 80 decreased the size of hydroxyapatite in some extent.

关 键 词：水热法 羟基磷灰石 有机修饰剂 粒径 生物相容性 

分 类 号：R318[医药卫生—生物医学工程]