静息态脑功能技术对平衡针治疗中枢机制的分析应用  

Resting state-functional magnetic resonance imaging technology applied to a balancing acupuncture treatment for central mechanisms

作　　者：叶泳松[1,2] 刘波[1,2] 陈志光[1,2] 

机构地区：[1]广州中医药大学第二临床医学院 [2]广东省中医院影像医学部,广东省广州市510120

出　　处：《中国组织工程研究与临床康复》2011年第48期8998-9002,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：广州中医药大学科研创新基金(编号:09CX068);课题名称:运用磁共振脑功能成像技术探索平衡针治疗腰椎间盘突出症的中枢机制~~

摘　　要：背景:平衡针治疗疾病疗效显著,但缺乏相关现代科学理论机制。目的:利用静息态脑功能成像技术探讨平衡针疗法的中枢作用机制。方法:纳入10例腰椎间盘突出腰腿痛患者及10例正常受试者,于平衡针针刺前后进行功能磁共振扫描,通过AFNI软件对与双侧杏仁核表现为显著联系的脑区进行功能连接分析,并对平衡针刺后腰椎间盘突出患者及正常受试者的脑功能连接的差异进行探讨。结果与结论:经平衡针治疗后10例腰椎间盘突出患者疼痛均有好转。脑功能连接分析显示腰椎间盘突出患者丘脑、脑干、腹前核、腹外侧核、额内侧回、额上回、额叶眶上回、额下回、颞上回、颞中回、海马回、扣带回、岛叶等脑区功能连接增强。正常受试者双侧颞中回、双侧眶上回、双侧尾状核头、双侧岛叶、左侧腹背侧核、双侧额上回、左侧额中回、前扣带回、右侧顶下小叶与杏仁核连接增强;双侧小脑齿状核、小脑蚓、左侧小脑坡、双侧舌回、左侧枕中回、右侧额上回、右侧中央前回、双侧顶下小叶、右侧顶上小叶、右侧中央后回与杏仁核连接下降。提示通过静息脑功能成像技术对杏仁核的研究有助于更深入理解平衡针灸治疗腰腿痛的中枢机制。BACKGROUND：Balanced acupuncture treatment for the disease has a significant effect,but lack of modern scientific theories relate to the mechanism.OBJECTIVE：To investigate the central mechanism of balancing technique acupuncture by using resting-state functional magnetic resonance imaging（fMRI）.METHODS：Ten healthy volunteers and 10 backleg pain patients with lumbar disc protrusion were examined by fMRI before and after balancing technique acupuncture.The encephalic regions which remarkably related to bilateral amygdala were analyzed by AFNI software,and the differences in brain functional connectivity of healthy volunteers and the lumbar disc protrusion patients were investigated after balancing acupuncture.RESULTS AND CONCLUSION：After balancing acupuncture treatment,the pain of 10 lumbar disc protrusion patients has been improved.The brain region of increased functional connectivity included thalamus,brain stem,ventral anterior nucleus,ventral lateral nucleus,medial frontal gyrus,superior frontal gyrus,frontal supraorbital gyrus,inferior frontal gyrus,superior temporal gyrus,middle temporal gyrus,hippocampus,cingulate gyrus and insula.Bilateral middle temporal gyrus,supraorbital gyrus,head of caudate nucleus,insula and left dorsal thalamus,bilateral superior frontal gyrus,left middle frontal gyrus,anterior cingulate gyrus and right inferior parietal lobule of the healthy volunteers cenhanced their connection with amygdala after balancing acupuncture.And bilateral dentate body of cerebellum,vermis,left cerebellum slope,bilateral lingual gyrus,left middle occipital gyrus,right superior frontal gyrus,right precentral gyrus,bilateral inferior parietal lobule,right superior parietal lobule,and right postcentral gyrus decreased their connection with amygdale.The research on amygdale through resting state fMRI is helpful to deeply comprehend the central mechanism of balancing technique acupuncture on backleg pain.

关 键 词：平衡针 腰腿痛 静息态脑功能成像 脑功能连接 杏仁核 中枢机制 

分 类 号：R318[医药卫生—生物医学工程]