ALA-PDT三阶段根除治疗方案治疗男性尿道口尖锐湿疣的临床疗效  

Three stages of 5-aminolevulinic acid-photodynamic therapy for condyloma acuminatum of external urethral meatus

作　　者：李捷[1] 易运连[1] 朱武[1] 

机构地区：[1]中南大学湘雅医院皮肤科,长沙410008

出　　处：《中南大学学报（医学版）》2011年第11期1115-1119,共5页Journal of Central South University ：Medical Science

摘　　要：目的:采用5-氨基酮戊酸(5-aminolevulinic acid,ALA)-光动力疗法(photodynamic therapy,PDT)三阶段根除治疗方案治疗男性尿道口尖锐湿疣,观察其临床疗效。方法:随机选择2009年1月至9月在中南大学湘雅医院皮肤科就诊的56例男性尿道口尖锐湿疣患者,采用ALA-PDT三阶段根除治疗方案每周治疗1次,连续3次。观察痊愈率、无效率、不良反应及并发症发生率,随访6个月观察复发率。结果:经ALA-PDT三阶段根除治疗方案治疗后,48例患者痊愈,痊愈率为85.7%;8例复发,复发率为14.3%;2例无效,无效率为3.6%。仅1例患者在治疗过程中出现明显疼痛,不良反应发生率为1.8%;无1例出现并发症。结论:采用ALA-PDT三阶段根除治疗方案治疗男性尿道口尖锐湿疣安全、高效,耐受性好,复发率低。Objective To observe the effect of the three stages of 5-aminolevulinic acid-photodynamic therapy（ALA-PDT） on condyloma acuminatum of external urethral meatus.Methods A tatal of 56 patients with condyloma acuminatum of external urethral meatus presenting at the Department of Dermatology of Xiangya Hospital from Janunary 2009 to September 2009 were randomly treated by the three stages of ALA-PDT.The topical ALA followed by PDT was carried out once a week for 3 weeks.Rates of cure,ineffectiveness,adverse effects and complications were observed.The follow-up time was 6 months and the recurrence rates were documented.Results After treatment of three stages of ALA-PDT,complete remission was achieved in 48 out of the 56 patients（85.7%）.The recurrence rate was 14.3%（8 cases）,and 2 patients had no responses（3.6%）.Only 1 patient had serious pain during the treatment,and the rate of adverse effect was 1.8%.No complications were observed.Conclusion The three stages of ALA-PDT are safe,effective and tolerant treatment for condyloma acuminatum of external urethral meatus.

关 键 词：5-氨基酮戊酸-光动力疗法 尖锐湿疣 尿道口 治疗 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]