舒洛地特联合厄贝沙坦对老年高血压肾损害的干预效应  

Therapeutic effects of sulodexide combined with irbesartan on elderly hypertensions with renal injury

作　　者：王丽丽[1] 余惠珍[1] 王大海[1] 洪富源[1] 舒贵阳[1] 

机构地区：[1]福建医科大学省立临床医学院,350001

出　　处：《中国医学创新》2011年第35期8-10,共3页Medical Innovation of China

摘　　要：目的观察舒洛地特和厄贝沙坦联合治疗老年原发性高血压伴微量白蛋白尿患者的临床疗效,为老年高血压肾损害的治疗寻求新途径。方法将76例老年原发性高血压合并微量白蛋白尿患者随机分为两组:舒洛地特+厄贝沙坦组(口服厄贝沙坦150 mg/d+口服舒洛地特250 LSU/次,2次/d)和厄贝沙坦组(口服厄贝沙坦150 mg/d),随访8周。观察两组治疗前后的尿微量白蛋白、血肌酐、血浆纤维蛋白原、凝血酶原时间、活化部分凝血酶时间、甘油三酯、总胆固醇指标的变化。结果治疗8周后,舒洛地特和厄贝沙坦联合干预比单用厄贝沙坦的尿微量白蛋白值降低更为显著(P<0.05)。与单用厄贝沙坦组比较,舒洛地特和厄贝沙坦联合干预后的血浆纤维蛋白原、甘油三酯和总胆固醇下降均较明显(P<0.05)。两组的血肌酐值在治疗前后比较差异均无统计学意义(P>0.05)。结论舒洛地特联合厄贝沙坦治疗老年原发性高血压合并微量白蛋白尿患者的安全性好,疗效显著优于单用厄贝沙坦治疗。Objective To investigate the effects of combination therapy of sulodexide and irbesartan on early stage renal injury caused by elderly primary hypertension, and to seek new treatment method for primary hypertensive kidney injury. Methods 76 patients with essential hypertension with early stage renal injury were randomly divided into control group（ n = 38 ） and combined treatment group （n =38）. The control group was treated with irbesartan （irbesartml 150 mg/d）, and the treatment group received the combination therapy of suledexide and irbesartan（ sulodexide 250 LSU bid, irhesartan 150 mg/d）. After g weeks, urine microalbumin,levels of creatinine, plasma fibrinogen, prothrombin time, activated partial thrombin time, triglyceride, and total cholesterol were measured and compared between the two groups. Results After eight weeks of treatment, the excretion value of microalbuminria in two groups patients were reduced obviously （ P 〈 0. 05 ）, with significant difference in combined treatment group compare with control group （P 〈 0. 05 ）. Plasma fibrinogen, triglycerin, and total cholesterol were obviously decreased in Sulodexide ＋ irbesartan group compared with control group after 8 weeks＇treatment （P 〈 0. 05 ）. There was no significant difference in serum creatinine in two groups after treatment than pre - treatment （ P 〉 0. 05 ）. Conclusion Sulodexide combined irbesartan is safe and effective in treating early stage renal injury caused by elderly primary hypertensives, and the resuits are significantly more effective than those treated with irbesartan alone.

关 键 词：舒洛地特 厄贝沙坦 原发性高血压 微量白蛋白尿 

分 类 号：R544.1[医药卫生—心血管疾病]