缬沙坦对非勺型高血压患者血压昼夜节律的影响  

Effect of valsartan on blood pressure diurnal rhythm in patients with non-dipping hypertension

作　　者：李亚雄[1] 曾文双[1] 邓远飞[1] 

机构地区：[1]北京大学深圳医院VIP病房,广东深圳518036

出　　处：《岭南心血管病杂志》2011年第6期454-455,共2页South China Journal of Cardiovascular Diseases

摘　　要：目的观察缬沙坦对非勺型高血压患者血压昼夜节律的影响。方法选择经24 h动态血压监测且诊断为非勺型2级高血压的患者60例为研究对象,将其按电脑数字表法随机均分为治疗组30例:上午7:00和晚上7:00各服缬沙坦80 mg;对照组30例:上午7:00服缬沙坦160 mg,两组用药8周后复测24 h动态血压。比较两组血压昼夜节律的变化。结果两组治疗后24 h、白昼、夜间收缩压及舒张压均较治疗前显著下降,差异有统计学意义(P<0.05)。治疗组的夜间收缩压、舒张压及白昼、夜间血压负荷较对照组显著下降,差异有统计学意义(P<0.05)。治疗组血压昼夜节律改变有效率明显高于对照组,差异有统计学意义(收缩压:73.33%vs.46.67%,P<0.05;舒张压:76.67%vs.43.33%,P<0.01)。结论应用缬沙坦治疗非勺型高血压,可以很好地控制2级高血压,并改变血压昼夜节律,早晚两次服用,效果更好。Objectives To observe the effect of valsartan with defferent dose and time on blood pressure diurnal rhythm in patients with non-dipper hypertension. Methods A total of 60 patients with miderate essential hypertension （EH） were randomly divided into two groups： treatment group （n=30） were treated with 80 mg at 7 AM valsartan and 80 mg valsartan at 7 PM; and control group （n=30） were treated with 160 mg valsartan at 7 AM. The changes of 24 h blood pressure and blood pressure diurnal rhythm before treatment and 8 weeks later were compared. Results The 24 h, day and night average systolic blood pressure （SBP）, diastolic blood pressure （DBP） of two groups all significantly decreased after treatment（P〈0.01 ）. The night average SBP and DBP, day load of blood pressure, night load of blood pressure of treatment group significantly decreased when compared with those of control group （P〈0.05）. Compared with control group, the effectiveness rates of diurnal rhythm of SBP （73.33% vs. 46.67%, P〈0.05）） and DBP （76.67% vs. 43,33%, P〈0.01 ） of treatment group significantly increased, Conclusions Valsartan can effectively decrease blood pressure and change day and night rhythm in patients with non-dipper hypertension by taken 80 mg twice a day.

关 键 词：高血压 缬沙坦 动态血压监测 

分 类 号：R544.1[医药卫生—心血管疾病]