辛伐他汀对心力衰竭患者心脏功能及左心室重构的影响  

Effect of simvastatin on cardiac function and left ventricular remodeling in patients with heart failure

作　　者：李国锋[1] 孙立伟[1] 黎笑冰[1] 

机构地区：[1]东莞市人民医院,广东东莞523018

出　　处：《岭南心血管病杂志》2011年第6期467-469,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的观察小剂量辛伐他汀对心力衰竭患者心脏功能及左心室重构的影响。方法选取2008年1月至2009年7月东莞市人民医院确诊为非缺血性心力衰竭的患者61例为研究对象。按电脑随机数字表法将入选对象分为观察组(n=30)与对照组(n=31),观察组在标准心力衰竭治疗基础上加服辛伐他汀(20 mg/d,治疗期6个月)。比较两组治疗前后患者心脏功能、生化指标的变化。结果经过6个月的治疗,观察组纽约心脏协会心功能分级[(2.0±0.4)级vs.(2.5±0.4)级,P<0.01]和左心室射血分数(58.7%±5.2%vs.43.0%±5.7%,P<0.01)显著改善,差异有统计学意义;对照组纽约心脏协会心功能改善,差异有统计学意义[(2.1±0.4)级vs.(2.4±0.4)级,P<0.05];左心室射血分数有改善的趋势,但差异无统计学意义(47.6%±5.3%vs.40.9%±6.3%,P=0.052)。结论非缺血性心力衰竭患者在标准心力衰竭治疗的基础上加用辛伐他汀治疗安全、有效,可显著改善该类患者左心室重构与心功能状态。Objectives To observing the effect of simvastatin on cardiac function and left ventficular remodeling in patients with heart failure. Methods Sixty one cases with non-ischemic heart failure were randomly divided into observation group （n=30） and control group （n=31） in The People＇s Hospital of Dongguan from Jan 2008 to Jul 2009. The two groups were given conventional therapy. Observation group was given simvastatin 20 mg/d in a course of 6 months. Heart function and biochemical changes of the two groups were observed and compared. Results After 6 months of treatment, the New York Heart Association （NYHA） classification [（2.0±0.4） grade vs. （2.5±0.4） grade, P〈0.01 ]and left ventrieular ejection fraction （LVEF） [58.7% ± 5.2% vs. 43.0% ± 5.7%, P〈0.01 ]of observation group were improved significantly （P〈0.01）. NYHA classification of control group was improved [ （2.1±0.4） grade vs. （2.4±0.4） grade, P〈0.05]. LVEF of control group showed improved tendence, but had no significance （47.6% ± 5.3% vs. 40.9% ± 6.3%,P=0.052）. Conclusions Patients with non-ischemic heart failure treated with simvastatin on the base of conventional treatment can significantly improve cardiac function and left ventricular remodeling, and it is safe and effective.

关 键 词：心力衰竭 心室重构 心脏功能 辛伐他汀 

分 类 号：R541.61[医药卫生—心血管疾病]