抗环瓜氨酸肽抗体与系统性红斑狼疮伴发关节炎的相关性研究  

Clinical significance of anti-cyclic citrullinate peptides antibody in systemic lupus erythematosus

作　　者：陈学琴[1] 汪国生[1] 赵小娟[1] 张宏[1] 李向培[1] 

机构地区：[1]安徽医科大学附属省立医院风湿免疫科,合肥230001

出　　处：《安徽医学》2011年第9期1217-1220,共4页Anhui Medical Journal

基　　金：国家自然科学基金(项目编号:81072462);安徽省高校省级自然科学研究项目(项目编号:KJ2009B072);安徽省自然科学基金(项目编号:090413253)

摘　　要：目的研究抗环瓜氨酸肽(CCP)抗体在系统性红斑狼疮(SLE)患者中的临床意义,探讨抗CCP抗体与SLE患者伴发关节炎、骨侵蚀破坏的关系及判断预后的意义。方法采用酶联免疫吸附试验(ELISA)法和速率比浊法检测145例SLE患者血清中抗CCP抗体和IgM-RF。结果抗CCP抗体在SLE患者中的阳性率为24.1%。抗CCP抗体阳性的SLE患者关节炎的发生率明显高于抗CCP抗体阴性者(77.1%与38.2%,P<0.05)。SLE伴发关节炎组抗CCP抗体阳性率(39.1%)高于非关节炎组(10.5%)(P<0.05);抗CCP抗体阳性组RF阳性率(38.5%)高于抗CCP抗体阴性组(24.4%)(P<0.05)。抗CCP抗体阳性患者较阴性患者侵蚀性关节炎的比例显著升高(25.7%与4.6%,P<0.01)。结论 24.1%的SLE患者出现抗CCP抗体,抗CCP抗体的出现与SLE伴发关节炎和骨关节侵蚀性破坏密切相关。Objective To invesigate the clinical significance of anti-cyclic citrullinated peptides antibodies（anti-CCP） in systemic lupus erythematosus（SLE） patients with arthritis,and to explore the association of anti-CCP with erosive arthritis and judge prognosis in SLE patients.Methods 145 SLE patients were examined for anti-CCP and IgM-RF with enzyme-linked immunosorbent assay method and rate turbidimetric method.Results The frequency of ant-CCP was 24.1% in this group of SLE patients.The frequency of arthritis was significantly higher in SLE patients with anti-CCP than without anti-CCP（77.1% VS 38.2%,P〈0.05）.Anti-CCP antibodies were more frequently detected in SLE patients with arthritis than those without arthritis（39.1% VS 10.5%,P〈0.05）.The frequency of RF-positive group with Anti-CCP than that without anti-CCP was（38.5% VS 24.4%,P〈0.05）.When compared with anti-CCP negative patient,erosive arthritis occurred more often in anti-CCP positive patients than nagative anti-CCP patients（25.7% VS 4.6%,P〈0.001）.Conclusion Anti-CCP antibodies have a prevalence in our group of SLE patients and its presence is closely associated with erosion of bone and joint destruction.

关 键 词：红斑狼疮 系统性 关节炎 抗环瓜氨酸肽抗体 

分 类 号：R593.241[医药卫生—内科学]