哌嗪催化Knoevenagel反应合成α,β-不饱和酸  

Synthesis of α,β-unsaturated acids by piperazine hexahydrate catalyzed Knoevenagel condensation reaction

作　　者：宋磊[1,2] 杨小生 朱海燕[2] 马琳[2] 

机构地区：[1]贵州师范大学化学与材料科学学院,贵州贵阳550001 [2]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002

出　　处：《化学试剂》2011年第12期1070-1072,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(30973620);贵州省优秀科技教育人才省长资金项目黔省专合字(2009)74号

摘　　要：以哌嗪为催化剂,芳香醛和丙二酸为原料,进行Knoevenagel合成反应,得到一系列的重要的有机合成中间体α,β-不饱和酸。产物通过1HNMR、13CNMR、IR、MS测试。此反应的特点是催化剂哌嗪的用量少,且价格低廉、低毒、反应温度较低、反应时间较短、有较高的产率(85%～95%)。α,β-Unsaturated acids were important intermediates in organic synthesis.The Knoevenagel condensation reacion under piperazine hexahydrate catalysis has been studied through reaction of various aldehydes and malonic acid,and a serious of products α,β-unsaturated acids were obtained.The structures were identified by the analysis of 1HNMR,13CNMR,IR and MS.The advantages of this procedure were that small amount of catalyst,low reaction temperature,short reaction time and high yields（85%～95%） were observed.Moreover,the catalyst was cheap,safe and low toxic.

关 键 词：哌嗪 KNOEVENAGEL反应 α β-不饱和酸 

分 类 号：O621.3[理学—有机化学]